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NCT Number: NCT07653789

Comparative Efficacy of Neuromobilization, Tendon Gliding Exercises, and Combined Techniques in Mild to Moderate Carpal Tunnel Syndrome

focuses on the comparative efficacy of Neuromobilization techniques, tendon gliding exercises, and their combined application in the management of mild to moderate Carpal Tunnel Syndrome through a randomized controlled trial (RCT)

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Key information

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Dr. Akbar Niazi teaching Hospital

Islamabad, ICT, Pakistan

Location status: Recruiting

Location contact

Gul Afsheen, DPT, MSPT MSK

CONTACT

[email protected]

+923435776966

About this study

Aims to provide valuable evidence regarding the comparative and combined effects of Neuromobilization and tendon gliding exercises in managing mild to moderate Carpal Tunnel Syndrome. The findings may help physiotherapists develop optimized treatment strategies for improving pain, hand function, and quality of life among CTS patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • • Symptoms of CTS (pain, paresthesia in the area of hand innervated by the median nerve)
  • First and Second Trimester Pregnant women.
  • Mild to Moderate CTS patients.
  • Individuals experiencing wrist pain for a duration of at least 6-8 weeks without a history of trauma or specific diagnosis (e.g., fracture, arthritis).
  • Pain rated between 3 and 5 on (NPRS).
  • Present neurological disorders (e.g., carpal tunnel syndrome, cervical radiculopathy).
  • No prior physical therapy treatment for wrist pain in the last 3-6 months

Exclusion criteria

  • • History of traumatic injury, fracture, or surgery to the wrist or hand.
  • Diagnosis of systemic diseases affecting the wrist (e.g., rheumatoid arthritis, gout, or diabetes-related neuropathy).
  • Any skin condition or infection around the wrist that would contraindicate physical therapy.
  • Third Trimester Pregnant women
  • Individuals with serious cardiovascular or metabolic disorders.
  • patients currently undergoing other treatments specifically targeting CTS (e.g., steroid injections)

Treatment and study plan

Combined Intervention Group

Other

will receive a combination of Neuromobilization techniques and tendon gliding exercises

Neuromobilization Group

Other

will receive Neuromobilization techniques targeting the median nerve.

Tendon Gliding Exercise Group

Other

will receive tendon Gliding exercises targeting the median nerve

Primary outcomes

  1. Pain Intensity

    Time frame: baseline, 3rd week, and 8th week.

    Measured using the Numeric Pain Rating Scale

  2. Functional Status and Symptom Severity

    Time frame: baseline, 3rd week, and 8th week

    Measured using the Boston Carpal Tunnel Questionnaire

Study contacts

Contact information is provided by the study sponsor or research team.

Gul Asheen, DPT, MSPT MSK

CONTACT

[email protected]

+923435776966

Sidra Hanif, DPT, MSNMPT, PhD PT

CONTACT

[email protected]

+923335985631

Sponsors and collaborators

Lead sponsor

Ibadat International University, Islamabad

Other

Registry information

Official study title

Comparative Efficacy of Neuromobilization Techniques, Tendon Gliding Exercises, and Combined Techniques in the Management of Mild to Moderate Carpal Tunnel Syndrome: A Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jun 17, 2026
Registry last updated
Jun 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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