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NCT Number: NCT06696638

Physiological Effects of Lung Impedance Tomography-Guided and Plat Pressure-Guided Phigh During APRV in Patients With ARDS

This study aims to investigate the effects of EIT-guided and Pplat-guided Phigh settings on regional ventilation and perfusion in ARDS patients during APRV, while also examining the impact of different Phigh settings on gas exchange, respiratory mechanics, and hemodynamics.

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Key information

Conditions

ARDS: Acute Respiratory Distress Syndrome Acute Lung Injury Lung Diseases Lung Injury Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Wuhan Union hospital

Wuhan, Hubei, 237000, China

Location status: Recruiting

Location contact

xiaojing Zou, MD

CONTACT

[email protected]

13995518630

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed with ARDS according to the 2023 global new definition of ARDS.
  • Age ≥ 18 years.

Exclusion criteria

  • Severe chronic obstructive pulmonary disease, severe asthma, pulmonary bullae, pneumothorax, subcutaneous emphysema, mediastinal emphysema, etc. · Contraindications for EIT, such as chest wound dressing, pacemaker implantation, defibrillator use, etc.
  • Pulmonary interstitial disease.
  • Uncorrected shock of various types.
  • Intracranial hypertension.
  • Pregnant and postpartum women.

Treatment and study plan

EIT-guided Phigh settings during APRV

Device

The Phigh level selected for the patients in the Intervention group was the intercept point of cumulated collapse and overdistension percentage curves, providing the best compromise between collapsed and overdistended lung.

Primary outcomes

  1. The effects of Phigh guided by different methods on regional lung ventilation assessed by EIT

    Time frame: 1 Hour Post-Intervention

Secondary outcomes

  1. Global inhomogeneity assessed by electrical impedance tomography

    Time frame: 1 Hour Post-Intervention

  2. Center of ventilation assessed by electrical impedance tomography

    Time frame: 1 Hour Post-Intervention

  3. ventilation/perfusion matching assessed by EIT

    Time frame: 1 Hour Post-Intervention

  4. Respiratory system compliance

    Time frame: 1 Hour Post-Intervention

    Tidal volume divided by plateau pressure

  5. mean arterial pressure

    Time frame: 1 Hour Post-Intervention

Study contacts

Contact information is provided by the study sponsor or research team.

jing Xiao Zou

CONTACT

[email protected]

+862785351606

Sponsors and collaborators

Lead sponsor

XiaoJing Zou,MD

Other

Collaborators

  • Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Registry information

Official study title

Physiological Effects of Lung Impedance Tomography-guided and Plat Pressure-guided Phigh During Airway Pressure Release Ventilation in Patients With Acute Respiratory Distress Syndrome

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Nov 20, 2024
Registry last updated
Jan 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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