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Completed

NCT Number: NCT01670747

Evaluation of the Lung Recruitment and End-expiratory Lung Collapse in Acute Respiratory Distress Syndrome (ARDS)

In this study gas-exchange and respiratory mechanics variations to PEEP change will be correlated to CT lung morphological modifications assessed at different airway pressures (5, 15, 30 and 45 cmH2O).

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Key information

Conditions

ARDS: Acute Respiratory Distress Syndrome Acute Lung Injury Lung Diseases Lung Injury Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Milan, 20122, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of acute lung injury/ acute respiratory distress syndrome
  • Mechanical ventilation

Exclusion criteria

  • Clinical diagnosis of chronic obstructive pulmonary disease
  • Clinical diagnosis of pneumothorax
  • Haemodynamic instability

Treatment and study plan

Chest computed tomography

Radiation

Primary outcomes

  1. Computer Tomography (CT) scan lung recruitment and CT lung weight

    Time frame: Study day (day 1)

    Aim of the study is to determine the relationship between the opening pressures (recruitment) and closing pressures (PEEP) in order to prevent the opening and closing of the lung parenchyma

Sponsors and collaborators

Lead sponsor

Policlinico Hospital

Other

Registry information

Official study title

Evaluation of the Lung Recruitment and End-expiratory Lung Collapse in Patients With Acute Respiratory Distress Syndrome

Important dates

Study start
2012
Primary completion
2015
Study completion
2015
First posted
Aug 22, 2012
Registry last updated
Mar 19, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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