Physical Activity, Fatigue, Social Support, and Psychological Well-Being in Women With Primary Hypothyroidism

Inclusion criteria

• Have a diagnosis of primary hypothyroidism (clinical or subclinical), established by a specialist in Endocrinology or Internal Medicine based on TSH and FT4 levels.
• Female.
• Are aged ≥18 years at the time of inclusion.
• Have stable treatment for thyroid dysfunction (levothyroxine dose or other replacement regimen without relevant modifications) for at least the previous 3 months, or a stable clinical condition if treatment is not required.
• Are able to ambulate independently in the community (with or without usual assistive devices), allowing participation in light to moderate physical activity.
• Are able to understand and complete the questionnaires independently.
• Have provided written informed consent

Exclusion criteria

• Have a diagnosis of severe medical conditions that predominantly limit the ability to perform physical activity independently of hypothyroidism (e.g., advanced heart failure, severe chronic respiratory disease).
• Have severe psychiatric disorders or significant cognitive impairment that hinder understanding of the information or reliable completion of the questionnaires.
• Have undergone major surgery, severe trauma, or an acute medical condition that has substantially limited physical activity in the three months prior to assessment.
• Are pregnant or in the immediate postpartum period, due to potential hormonal and functional interference with the study variables.
• Are concurrently participating in a clinical trial or a structured physical exercise program.