Photodynamic Therapy of Actinic Keratosis of the Face and Scalp With and Without Prior Curettage

Guidelines for photodynamic therapy (PDT) of actinic keratosis recommend pretreatment with curettage. The impact of curettage on the treatment effect is, however, not known. The present study aimed to evaluate whether daylight-PDT without curettage would reduce treatment effect compared to daylight-PDT with curettage.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Keratosis, Actinic Keratosis Neoplasms Precancerous Conditions Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Bispebjerg Hospital

Copenhagen NV, DK, 2400, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Multiple actinic keratosis on the forehead or scalp

Exclusion criteria

Known allergy to methyl aminolevulinate
Porphyria
Pregnancy
Lactation

Treatment and study plan

No curettage

Drug

Standard PDT without curettage

Curettage

Drug

Standard PDT

Primary outcomes

Complete lesion response rate

Time frame: Treatment efficacy was evaluated 3 months after PDT

Complete lesion response rate, was defined as the number of completely responding lesions divided by the total number of treated lesion in each field. Complete lesion response was defined as complete disappearance of the lesion both by palpation and visually.

Sponsors and collaborators

Lead sponsor

Bispebjerg Hospital

Other

Registry information

Important dates

Study start: 2017
Primary completion: 2017
Study completion: 2017
First posted: Oct 5, 2018
Registry last updated: Oct 9, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed