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NCT Number: NCT05766423

Phenotyping Adherence Through Technology-Enabled Reports and Navigation

This study is being conducted to adapt and pilot test a technology-enabled, primary care strategy for routinely monitoring medication use and adherence among older adults with multiple chronic conditions and polypharmacy.

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Key information

Conditions

Medication Adherence Behavior Health Behavior Patient Acceptance of Health Care Patient Compliance Treatment Adherence and Compliance

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Northwestern University

Chicago, Illinois, 60611, United States

About this study

Our study aims are to:

Aim 1: Adapt the PATTERN intervention for use in primary care using input from key stakeholders. During Aim 1, the Northwestern research team will solicit opinions from key informants (patients, clinicians, practice administrators) to ensure PATTERN meets the needs of primary care.

Aim 2: Assess the PATTERN intervention's feasibility and acceptability for use in primary care. During Aim 2, the investigators will conduct a 2-arm, patient-randomized controlled trial at a Northwestern Medicine primary care practice. Participants will be recruited and randomly assigned, using a random number generator application, to either the PATTERN intervention or usual care. Usual care refers to the normal standard clinical practices at the participating practice. Participants will be followed for 6 months.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Each participant must:

  • Be an adult aged 65 or older
  • Speak English as their primary language
  • Have multiple chronic conditions
  • Be prescribed 8 or more medications
  • Be primarily responsible for administering own medication
  • Receive medical care at the participating primary care practice
  • Have access to the internet and an active email address
  • Be signed up for the patient portal (MyChart)

Exclusion criteria

No participant can:

  • Have severe, uncorrectable visual, hearing or cognitive impairments that would preclude study consent or participation

Treatment and study plan

The PATTERN Intervention

Behavioral

The intervention components include:

  • An adherence assessment that requests patients to self-report via MyChart about their medication use. The assessment provides a link between the health center and the patient ahead of a regularly scheduled clinic visit.
  • Care alert notifications directed to a nurse pool and/or member of the clinical care team when a medication adherence related problem is identified by the adherence assessment. The alert will also include the type of problem the patient is experiencing (cognitive, psychological, medical, regiment, social and/or economic). Once they receive these alerts, the care team can then activate appropriate staff and/or resources to respond.

Primary outcomes

  1. Medication Adherence

    Time frame: About 2-4 Weeks

    Participants' medication adherence will be measured at about 2-4 weeks after their clinic visit using a validated self-report measure: ASK-12. The 12-item measure assesses general medication attitudes and beliefs across three domains: 1) inconvenience/forgetfulness, 2) treatment beliefs, and 3) behaviors. Response options range from "Strongly Disagree" to "Strongly Agree". Scores can range from 12-60 with higher scores representing greater barriers to adherence.

Secondary outcomes

  1. Fidelity

    Time frame: By the scheduled clinic visit (baseline)

    The investigators will examine participants' completion rates of the routine medication adherence assessment. This will be identified via the EHR.

Sponsors and collaborators

Lead sponsor

Northwestern University

Other

Collaborators

  • National Institute on Aging (NIA)
  • The Claude D. Pepper Older Americans Independence Centers

Registry information

Official study title

Phenotyping Adherence Through Technology-Enabled Reports and Navigation: The PATTERN Study

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Mar 13, 2023
Registry last updated
Jun 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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