Phenotypic Heterogeneity in Hemophilia A: An Investigation of the Role of Platelet Function

The is study will examine whether variation in clinical bleeding frequency and severity among boys with severe Hemophilia A (Factor VIII deficiency) is associated with variations in laboratory measurements of platelet activity.

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Key information

Conditions

Hemophilia A Blood Coagulation Disorders Blood Coagulation Disorders, Inherited Coagulation Protein Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Hematologic Diseases Hemic and Lymphatic Diseases Hemorrhagic Disorders

Age range

3 year–20 year

Sex eligibility

Male

Study type

Observational

Primary location

CancerCare Manitoba, Winnipeg, Manitoba, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

documented circulating FVIII level of ≤1%
age 3 - 20 years
may be on primary or secondary prophylaxis
granting of informed consent

Exclusion criteria

measurable inhibitor level at the time of enrollment
ingestion of aspirin/supplement known to influence platelet function within 14 days of blood sampling, or ibuprofen within 3 days

Treatment and study plan

Primary outcomes

Procoagulant platelet-derived microparticle formation

Time frame: At time of enrollment
Platelet aggregation

Time frame: At time of enrollment

Whole blood platelet aggregation responses

Sponsors and collaborators

Lead sponsor

CancerCare Manitoba

Other

Collaborators

Novo Nordisk A/S
The Hospital for Sick Children

Registry information

Important dates

Study start: 2014
Primary completion: 2015
Study completion: 2016
First posted: Aug 26, 2014
Registry last updated: Feb 3, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed