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NCT Number: NCT07614685

Phase Resolved Functional Lung MRI and Oscillometry for the Observation of Healthy Lung Function

This study will examine the relationship of airways resistance measured by oscillometry with ventilation defects measured by Phase Resolved Functional Lung (PREFUL) MRI in healthy human subjects.

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Key information

Conditions

Breathing Healthy Lung Function Decreased MRI Imaging Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Aspiration Respiratory Insufficiency Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Rochester Medical Center

Rochester, New York, 14642, United States

Location contact

Partick Donohue, MD

CONTACT

[email protected]

585-210-9301

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 years or older
  • Ability to provide consent
  • Willingness to perform MRI and breathing test
  • Must be able to speak and understand English

Exclusion criteria

  • Pregnant
  • Unable or willing to provide consent or perform the required maneuvers for testing.

Treatment and study plan

Airway Oscillometer

Device

The termoflo c-100 Airwave Oscillometer System is intended to measure respiratory system impedance using the Forced Oscillation Technique (FOT).

Phase Resolved Functional Lung MRI

Diagnostic Test

The Phase Resolved Functional Lung (PREFUL) MRI technique acquires images of the lung so that measures of ventilatory defect percentage can be calculated.

Primary outcomes

  1. Oscillometer

    Time frame: Single measurement, approximately 1 day

    The oscillometer will collect an airway impedance measurement which is made up of multiple variables.

  2. Phase Resolved Functional Lung (PREFUL) MRI

    Time frame: Single measurement, approximately 1 day

    PREFUL MRI will acquire images of the lungs and a measurement called the ventilatory defect percentage (or VDP) will be calculated.

Study contacts

Contact information is provided by the study sponsor or research team.

Patrick Donohue, MD

CONTACT

[email protected]

585-210-9301

Sponsors and collaborators

Lead sponsor

University of Rochester

Other

Registry information

Acronym: PROOF

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
May 29, 2026
Registry last updated
May 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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