Body Composition Related Evaluation of Airway Tone and Hyper-rEactivity Using Oscillometry

This study will determine if airway resistance to airflow and pressure, measured by Oscillometry, is associated with abnormal findings on methacholine challenge testing and whether these findings are associated with body habitus,

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Key information

Conditions

Breathing Asthma Asthma (Diagnosis) Body Weight Bronchial Diseases Disease Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Lung Function Decreased Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Aspiration Respiratory Hypersensitivity Respiratory Insufficiency Respiratory Tract Diseases Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Rochester Medical Center

Rochester, New York, 14620, United States

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Willingness to perform breathing test
Must be able to speak and understand English
Referred for Methacholine Challenge Test

Exclusion criteria

Unable to provide consent or perform oscillometry test

Treatment and study plan

Oscillometer

Device

The tremoFlo C-100 Airwave Oscillometry System is intended to measure respiratory system impedance using the Forced Oscillation Technique (FOT).

Primary outcomes

Oscillometer

Time frame: Single measurement, approximately day 1

The oscillometer will collect an airway impedance measurement which is made up of multiple variables.

Study contacts

Contact information is provided by the study sponsor or research team.

Patrick Donohue, MD

CONTACT

[email protected]

(585) 210-9301

Sponsors and collaborators

Lead sponsor

University of Rochester

Other

Registry information

Acronym: BREATH-OSC

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2027
First posted: Jan 21, 2026
Registry last updated: Apr 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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