Pharmacokinetics of Patupilone After a Single Intravenous Administration in Patients With Advance Solid Tumor Malignancies.

Inclusion criteria

• 18 years or older
• World Health Organization (WHO) Performance Status Score of: 0- you are fully active and more or less as you were before your illness, 1 - you cannot carry out heavy physical work, but can do anything else.
• Adequate hematological laboratory parameters
• No major impairment of renal or hepatic function
• Female patients must have a negative serum pregnancy test at screening.

Exclusion criteria

• Severe and/or uncontrolled medical disease;
• Severe cardiac insufficiency with uncontrolled and/or unstable cardiac or coronary artery disease;
• Known diagnosis of human immunodeficiency virus (HIV) infection;
• Presence of any other active or suspected acute or chronic uncontrolled infection;
• Symptomatic brain metastases or leptomeningeal disease.

Other protocol-defined inclusion/exclusion criteria may apply.