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OpenTrials
Completed

NCT Number: NCT04164199

Study of Tislelizumab, Pamiparib, and Other Investigational Agents in Participants With Advanced Malignancies

This is an open-label, multicenter, extension study to evaluate the long-term safety and efficacy of BeiGene or BeOne investigational drugs in participants with advanced malignancies who participated in a prior BeiGene- or BeOne-sponsored clinical study (parent study).

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Prince of Wales Hospital, Randwick, New South Wales, Australia

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About this study

For the purposes of this study, "study treatment" will refer to all investigational agents. A parent study is defined as the original BeiGene- or BeOne-sponsored clinical trial in which the participant was initially enrolled and received BeiGene or BeOne investigational drugs (with or without other treatments).

Note: Our company, previously known as BeiGene, is now officially BeOne Medicines. Because some of our older studies were sponsored under the name BeiGene, you may see both names used for this study on this website.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Key Inclusion Criteria:

  • Currently participating in a BeiGene- or BeOne-sponsored eligible parent study
  • Fulfills treatment criteria specified in the parent study protocol
  • In the opinion of the investigator, the participant will continue to benefit from and tolerate any of the parent study treatments.
  • The first dose of study treatment in the LTE study will be received within the treatment interruption period allowed by the parent study:
  • "Treatment interruption" is an unplanned pause in study treatment (eg, due to adverse event). Restarting study treatment beyond the interruption period allowed by the parent study will be determined by the investigator and the sponsor.

Key Exclusion Criteria:

  • Permanently discontinued from all investigational drugs in the parent study due to unacceptable toxicity, noncompliance with study procedures, or withdrawal of consent
  • Have uncontrolled active systemic infection or recent infection requiring parenteral antimicrobial therapy prior to the start of the extension study
  • Have a medical condition or organ system dysfunction that in the investigator's opinion, could compromise the participant's safety, interfere with the absorption or metabolism of investigational drugs, or put the study outcomes at undue risk
  • Underwent treatment with any systemic anticancer treatment (other than treatment permitted in the parent study) during the time between the last treatment in the parent study and the first dose of study treatment in the LTE study
  • Pregnant or lactating women

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.

Treatment and study plan

Tislelizumab

Drug

Administered intravenously.

Other names: BGB-A317

Pamiparib

Drug

Administered orally.

Other names: BGB-290

Temozolomide

Drug

Administered orally.

Sitravatinib

Drug

Administered orally.

Ociperlimab

Drug

Administered intravenously.

Other names: BGB-A1217

BAT1706

Drug

Administered intravenously.

FRUQUINTINIB

Drug

Administered orally.

BGB-15025

Drug

Administered orally.

Zanidatamab

Drug

Administered intravenously.

Other names: ZW25

BGB-A445

Drug

Administered intravenously.

Other names: Gimistotug

Surzebiclimab

Drug

Administered intravenously.

Other names: BGB-A425

Lenvatinib

Drug

Administered orally.

LBL-007

Drug

Administered intravenously.

Other names: Alcestobart

Primary outcomes

  1. Number of Participants with Immune-Mediated Adverse Events, Serious Adverse Events, and Adverse Events Grade 3 or Higher

    Time frame: up to 7 years

    Safety as assessed by the number of participants with immune-mediated adverse events (imAEs), ≥ Grade 3 adverse events, and serious adverse events.

Sponsors and collaborators

Lead sponsor

BeOne Medicines

Industry

Registry information

Official study title

An Open-Label, Multicenter, Long-Term Extension Study of Treatment With Tislelizumab, Pamiparib, and Other Investigational Agents in Patients With Advanced Malignancies

Important dates

Study start
2019
Primary completion
2026
Study completion
2026
First posted
Nov 15, 2019
Registry last updated
Jun 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.