Skip to main content
OpenTrials
Completed

NCT Number: NCT06313047

Pharmacogenetic of Doxorubicin in HCC.

The study included 81 HCC patients, both male and female. Prior to being assessed for eligibility, each recruited patient with HCC received a comprehensive review of their medical history, physical status, and laboratory results. Every research participant take part in the experiment and provided written informed consent.

Completed

Looking for future studies?

Notify Me

Key information

Age range

20 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

King Abdullah bin Abdulaziz University Hospital

Riyadh, Saudi Arabia

About this study

All patients had their baseline viral indicators for HBV and HCV evaluated. Additionally, blood samples were taken for genotyping. All patients underwent evaluations of their kidney, liver, and alpha fetoprotein (AFP) functions, as well as their complete blood count (CBC), at both the baseline and follow-up appointments. To evaluate the efficacy of TACE, triple pelvic abdominal CT scans were performed both prior to and one month later. Using triphasic pelviabdominal CT, patients who achieved complete response (CR) were monitored for up to 13 months following chemotherapy in order to identify recurrence. Follow-up appointments were planned to identify patients responces or any negative effects.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • When diagnosing the patient with HCC, the guidelines provided by the American Association for the Study of Liver Diseases (AASLD) were adhered to.
  • Be above 20 years old.
  • Individuals with intact organs.
  • There is no cure for HCC in surgery, microwave treatment, or radiofrequency ablation.

Exclusion criteria

  • The patients refused to sign the formal consent.
  • Be more than 75 years old.
  • There is a notable case of portal vein thrombosis.
  • Spreads beyond the liver.
  • Encephalopathy of the liver.
  • Present sickness.

Treatment and study plan

Doxorubicin

Drug

each recruited patient with HCC received a comprehensive review of their medical history, physical status, and laboratory results.

Other names: Dox

Primary outcomes

  1. GSTP1

    Time frame: 1 year

    Genotyping

  2. CYP2B6

    Time frame: 1 year

    Genotyping

Sponsors and collaborators

Lead sponsor

Rehab Werida

Other

Collaborators

  • King Abdulaziz University
  • King Saud Bin Abdulaziz University for Health Sciences

Registry information

Official study title

Pharmacogenetic of Doxorubicin in Patients With Hepatocellular Carcinoma: A Prospective Cohort Study

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
Mar 15, 2024
Registry last updated
Mar 28, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.