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NCT Number: NCT05796102

PET-MRI Esophagus Feasibility Study

This is a single arm, single centre, investigator initiated study to investigate the feasibility of using PET-MRI imaging in radiation treatment workflow in up to 15 patients with esophagogastric cancer. PET-MRI imaging will be completed before the start of radiation treatment. MRI imaging will be completed during radiation treatment and after radiation treatment. These images will not be used to plan the radiation treatment and routine clinical care will be provided.

The goal of this study is to gather information that will allow the radiation team to include MRI and PET imaging into the radiation treatment workflow for patients with esophageal cancer receiving radiation therapy in the future.

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Key information

Conditions

Esophagogastric Cancer

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Princess Margaret Cancer Centre

Toronto, Ontario, Canada

Location status: Recruiting

Location contact

Melissa Bartolo Rego

CONTACT

[email protected]

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients 18 years or older
  • Diagnosed with locally advanced esophageal cancer being considered for conventional RT >4 weeks
  • Ability and willingness to provide written informed consent

Exclusion criteria

  • Contraindication for MRI
  • Contraindication for Gadolinium (i.e. inability to lie supine for at least 60 minutes)
  • Any patient who is pregnant or breastfeeding
  • Pacemaker or implanted defibrillator
  • Claustrophobia

Treatment and study plan

PET-MRI

Procedure

A PET/MRI scan is a two-in-one test that combines images from a positron emission tomography (PET) scan and a magnetic resonance imaging (MRI) scan. Magnetic Resonance Imaging (MRI) provides better soft tissue contrast compared to conventional computerized tomography (CT), and when combined with PET, can potentially provide better visualization of the tumor shape, size, and position.

Additional MRI imaging will be completed once during radiation treatment, and once after radiation treatment

Primary outcomes

  1. Feasibility of PET-MRI to visualize and assess impact of RT treatments on esophagogastric tumors

    Time frame: 2 years

    Detection of metastases on DWI and gadolinium enhanced T1-weighted 3D VIBE sequences.

Secondary outcomes

  1. Difference in manual GTV segmentation using PET-MRI

    Time frame: 2 years

    Differences in manual GTV segmentation between standard of care treatment plan and study generated treatment plan using PET-MRI.

  2. Quantification of dosimetric advantages of PET-MRI treatment plan

    Time frame: 2 years

    Comparison of dosimetry properties between the standard of care treatment plan and study generated treatment plan using PET-MRI.

Study contacts

Contact information is provided by the study sponsor or research team.

Rebecca K S Wong, MD

CONTACT

[email protected]

4169462000 ext. 5736

Sponsors and collaborators

Lead sponsor

University Health Network, Toronto

Other

Registry information

Official study title

Feasibility Study of PET-MRI as a Platform for Image Guidance and Adaptive Radiation Therapy in Patients With Esophagogastric Cancer

Acronym: PET-MRI

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
Apr 3, 2023
Registry last updated
Mar 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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