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OpenTrials
Active, Not Recruiting

NCT Number: NCT05612048

A Study of Tooth Erosion in People With Esophagogastric Cancer

The researchers are doing this study to find out more about what may lead to the loss of tooth enamel (the thin outer covering of the tooth) and how often it happens in people with esophagogastric cancer, colorectal cancer, pancreatic cancer, breast cancer, head and neck cancer, or non-small cell lung cancer, or a healthy volunteer.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Esophagogastric Cancer Deglutition Disorders Digestive System Diseases Esophageal Diseases Esophageal Motility Disorders Gastroesophageal Reflux Gastrointestinal Diseases Stomatognathic Diseases Tooth Demineralization Tooth Diseases Tooth Erosion Tooth Wear

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, 10065, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subject is willing and able to provide written informed consent.
  • Patients with a history of esophagogastric, HNSCC, PDAC, CRC, or NSCLC or healthy controls
  • Patients must be able to fully comprehend and complete the survey and be willing to have pictures taken of their teeth with a camera or intra-oral camera.
  • Patients must be able to understand English language or have access to adequate translation services.
  • Age ≥ 18 years old.

Exclusion criteria

  • Subjects without evaluable molars or with significant molar dental work precluding dentists from assessing enamel status, Note: evaluable is defined as having bilateral assessable mandibular molars, or erosions present in the remaining assessable quadrants.
  • For healthy controls only, patients cannot have a non-skin cancer history nor presenting for a procedure evaluating reflux symptoms.

Treatment and study plan

Survey

Other

This is a 15-item questionnaire. The questionnaire asks subjects to quantify, during a specified duration of time, the number of times they have consumed or completed a task (ex. alcohol intake, cigarette use, and teeth brushing frequency). Additionally, the questionnaire further asks subjects to quantify their GERD symptoms and risk factors prior to diagnosis. All study procedures will be completed in one visit as part of a standard-of-care clinic visit.

Intra-oral camera

Other

Intraoral pictures of molars and incisors in 13 key regions

Optional Salvia sample

Other

Cohort 1 only. Participant is responsible for collecting and bringing the salvia sample to clinic.

Primary outcomes

  1. The incidence of dental erosions

    Time frame: 1 year

    scored with a modified BEWE index.

Sponsors and collaborators

Lead sponsor

Memorial Sloan Kettering Cancer Center

Other

Registry information

Official study title

Pilot Study of Dental Erosion as a Non-invasive Biomarker of Esophagogastric Cancer

Important dates

Study start
2022
Primary completion
2027
Study completion
2027
First posted
Nov 10, 2022
Registry last updated
Mar 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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