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NCT Number: NCT07653048

Personality Traits and Biochemical Risk Phenotypes

This prospective observational study investigates the association between personality traits and routine laboratory abnormalities in adults undergoing routine health assessment. Personality traits are assessed using the Five-Factor Personality Inventory (FFPI), while biochemical data are obtained from routine laboratory testing, including markers of glycemic status, liver function, lipid metabolism, renal function, and complete blood count parameters.

The primary objective of the study is to evaluate the association between FFPI personality trait scores and the total number of laboratory abnormalities identified during routine clinical evaluation. Secondary analyses will examine associations between personality traits and glycemic status, fasting plasma glucose concentration, liver function markers, lipid profile parameters, renal function indicators, complete blood count parameters, and the total number of laboratory abnormalities.

The findings may contribute to a better understanding of the relationship between psychological characteristics and biological health indicators and may support the development of more personalized approaches to health promotion, risk assessment, and disease prevention.

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Key information

Conditions

PreDiabetes Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Hyperglycemia Hyperinsulinism Insulin Resistance Metabolic Diseases Metabolic Syndrome Nutritional and Metabolic Diseases Prediabetic State

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Medical Center TOPMED

Târgu Mureş, Mureș County, 540058, Romania

Location status: Recruiting

Location contact

Stefania Diana Nilca, Principal Psychologist, PhD St

CONTACT

[email protected]

0745404037

About this study

The study is designed as a prospective observational cohort investigation conducted in adults undergoing routine health assessment. Participants complete the Five-Factor Personality Inventory (FFPI), and clinical and laboratory data are collected as part of routine medical evaluation.

Routine laboratory assessment includes fasting plasma glucose (mg/dL), gamma-glutamyl transferase (GGT, U/L), alanine aminotransferase (ALT, U/L), aspartate aminotransferase (AST, U/L), total cholesterol (mg/dL), serum creatinine (mg/dL), urea (mg/dL), estimated glomerular filtration rate (eGFR, mL/min/1.73 m²), and complete blood count parameters measured according to standard laboratory units. The total number of laboratory abnormalities is defined as the count of laboratory parameters outside their corresponding reference intervals. For the purposes of this study, the total number of laboratory abnormalities serves as an operational indicator of biochemical risk.

The primary objective of the study is to evaluate the association between Five-Factor Personality Inventory (FFPI) personality trait scores and the total number of routine laboratory abnormalities identified during clinical evaluation.

Secondary analyses will examine associations between personality traits and glycemic status, fasting plasma glucose concentration, liver function markers (GGT, ALT, and AST), lipid profile parameters, renal function indicators, and the total number of laboratory abnormalities.

Data are collected prospectively during routine clinical practice. Statistical analyses will evaluate the strength and direction of associations between personality traits and laboratory health indicators while accounting for relevant demographic and clinical variables.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 years or older
  • Undergoing routine health assessment
  • Completion of the Five-Factor Personality Inventory (FFPI)
  • Availability of routine laboratory test results
  • Provision of written informed consent

Exclusion criteria

  • Age younger than 18 years
  • Incomplete FFPI assessment
  • Missing or incomplete laboratory data
  • Refusal or inability to provide informed consent

Treatment and study plan

Primary outcomes

  1. Number of Laboratory Abnormalities

    Time frame: At baseline

    Total number of routine laboratory parameters outside their corresponding reference intervals, expressed as a count of abnormal laboratory findings. Laboratory parameters include fasting plasma glucose (mg/dL), gamma-glutamyl transferase (GGT, U/L), alanine aminotransferase (ALT, U/L), aspartate aminotransferase (AST, U/L), total cholesterol (mg/dL), serum creatinine (mg/dL), urea (mg/dL), estimated glomerular filtration rate (eGFR, mL/min/1.73 m²), and complete blood count parameters measured according to standard laboratory units.

Secondary outcomes

  1. Five-Factor Personality Inventory (FFPI) Scores

    Time frame: At baseline

    Personality traits assessed using the Five-Factor Personality Inventory (FFPI), including Neuroticism, Extraversion, Agreeableness, Conscientiousness, and Openness dimensions, expressed as standardized questionnaire scores.

  2. Glycemic Status

    Time frame: At baseline

    Classification of participants according to fasting plasma glucose (mg/dL) concentration measured during routine laboratory assessment as:

    Normoglycemia (<100 mg/dL) Prediabetes (100-125 mg/dL) Hyperglycemia (≥126 mg/dL or previously diagnosed diabetes mellitus)

Study contacts

Contact information is provided by the study sponsor or research team.

Stefania Diana St Nilca, Principal Psychologist, PhD St

CONTACT

[email protected]

+40745404037

Sponsors and collaborators

Lead sponsor

Medical Center TOPMED

Other

Collaborators

  • George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures

Registry information

Official study title

Personality Traits and Biochemical Risk Phenotypes in Adults Undergoing Routine Health Assessment

Acronym: PHEBiP

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Jun 17, 2026
Registry last updated
Jun 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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