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OpenTrials
Completed

NCT Number: NCT00929136

Peripheral Effects of Endotoxin on Insulin Resistance

The aim of the study is to isolate the direct effects of endotoxin on glucose, lipid and protein metabolism. Eight healthy volunteers are enrolled. The hypothesis is that endotoxin will induce insulin resistance, lypolysis and proteolysis acutely.

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Key information

Conditions

Healthy Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

The Medical Research Laboratories, Dept. M, Aarhus University Hospital

Aarhus, 8000, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Normal health
  • 22 < BMI < 28
  • Written Informed Concent

Exclusion criteria

  • Any disease
  • Any use of medication
  • Recent immobilization of a lower extremity

Treatment and study plan

USP endotoxin

Biological

Continuous intra-arterial infusion

Other names: USP Endotoxin, LOT: G3E069

Primary outcomes

  1. glucose concentration

    Time frame: 360 minutes observation

Secondary outcomes

  1. Regional arteriovenous amino-acid balance

    Time frame: measured at t=180 and 360 minutes

  2. Intra-cellular insulin signaling

    Time frame: measured at t=0, 120, and, 210 minutes

  3. Regional arteriovenous lipid balance

    Time frame: measured at t=180 and 360 minutes

Sponsors and collaborators

Lead sponsor

Aarhus University Hospital

Other

Registry information

Official study title

The Effect of Regional Inflammation on Metabolism and Insulin Sensitivity in the Lower Extremity.

Important dates

Study start
2009
Primary completion
2010
Study completion
2010
First posted
Jun 26, 2009
Registry last updated
Oct 4, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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