Periostin Levels in Children With Adenoid Hypertrophy

A total of 40 patients-age ranged between 2 and 12 years- were planned to enroll in the study prospectively. Patients that were scheduled to undergo adenoidectomy were included in the study group (adenoid group). The control group comprised of 20 healthy children who had previously been treated for anemia in the out-patient clinic of the Pediatrics Department and were clinically healthy with normal complete blood cell counts at their follow-up visits.

Serum samples were obtained from the two groups. The samples were centrifuged at 1500 g for 5 minute and stored in -80 oC for later analysis of periostin levels. Adenoid tissue and normal mucosal tissue samples were obtained from the adenoidectomy patients and stored in -80 oC for later homogenization and measurement of periostin levels.

Inclusion criteria

• The patients that were scheduled for adenoidectomy
• Healthy subjects that had not any kind of allergy, adenoid hypertrophy symptoms

Exclusion criteria

(for adenoid group):

• The subjects that had any kind of corticosteroid treatment 1 month prior to surgery, and antihistaminic treatment 2 weeks prior to surgery

Exclusion criteria

(for control group):

• To have allergic rhinitis symptoms
• To have high total IgE levels
• To have positive skin prick test
• To have acute respiratory tract infection
• To have asthma To have any kind of endocrin disease