Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07276646

Perioperative Opioid-sparing Effect of Retrosuperior Costotransverse Ligament Block Versus Erector Spinae Block in Laparoscopic Cholecystectomy

This study aims to compare the analgesic effect of retro superior costotransverse ligament space block vs erector spinae plane block to Achieve high-quality perioperative opioid-sparing effect and postoperative analgesia after laparoscopic cholecystectomy with optimum hemodynamic stability and high patient and surgeon satisfaction

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Perioperative Analgesia

Age range

21 year–64 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of human medicine, Zagazig university, Zagazig

Zagazig, Egypt

Location status: Recruiting

Location contact

Dina Salem, MD

CONTACT

[email protected]

01099333513 ext. 002

About this study

This study aims to compare between retro superior costotransverse ligament space block vs erector spinae plane block

  • To compare the analgesic outcomes (time to first analgesic request, total amount of analgesic consumption and pain scores by NRS)
  • To assess the block performance time required to perform each technique .
  • To compare intraoperative parameters (hemodynamics and intraoperative fentanyl consumption)
  • To assess patient, surgeon satisfaction and complications of the block.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patient acceptance
  • Age: 21-64 years old.
  • Sex: both sexes.
  • Physical status: ASA I & II.
  • Body mass index (BMI): 18.5 - 30 kg/m2.
  • Type of operations: elective laparoscopic cholecystectomy.
  • Duration of surgery not more than 2 hours.

Exclusion criteria

  • Known hypersensitivity to lidocaine or bupivacaine.
  • Patients with respiratory insufficiency.
  • Coagulation disorders or taking drugs affect surgical hemostasis.
  • Patients with pre-existing neurological deficits. 8. Uncooperative patient or with altered mental status. 9. Patient with advanced cardiovascular or respiratory diseases

Treatment and study plan

Retrosuperior costotransverse ligament block group

Procedure

The patient will receive retrosuperior costotransverse ligament block

Erector spinae block group

Procedure

The patient will receive erector spinae block.

Primary outcomes

  1. The time to first call to rescue analgesia

    Time frame: 24 hours

    The time to first call to rescue analgesia( the interval between the block injection till the NRS more than or equal 4) (naluphine) will be recorded

Secondary outcomes

  1. To assess block characteristics (block performance time)

    Time frame: 1 hour

    To assess block characteristics (block performance time) in minutes

  2. Total intraoperative fentanyl consumption

    Time frame: duration of surgery (up to 2 hours)

    Total intraoperative fentanyl required other than the induction dose in micrograms

  3. Pain intensity by Numerical Rating Scale

    Time frame: 30 minutes after arrival to post anesthesia care unit , 2hours, 4hours, 6hours, 8hours, 12hours, 18 hours and 24hours postoperative

    Analgesic parameters (Pain intensity at rest and at movement) by using Numerical Rating Scale (NRS) which will explained to patient as follows:0=no pain and 10= worst pain

  4. total amount of rescue analgesia

    Time frame: 24 hours

    total amount of rescue analgesia if NRS≥4. in the first 24 hours.

  5. Intraoperative hemodynamics (Heart Rate and Mean Arterial Pressure)

    Time frame: every 5 minutes in the first 30 minutes then every 10 minutes till the end of surgery

    Intraoperative hemodynamics every 5 minutes in the first 30 minutes then every 10 minutes till the end of surgery

  6. Patient's satisfaction

    Time frame: 24 hours

    all patient's satisfaction: The patients will be asked to rate the overall degree of satisfaction of the analgesia by using a 5-points likert-like verbal scale (1 = very dissatisfied analgesia, 2 = dissatisfied analgesia, and 3 = neutral, 4=satisfied analgesia, and 5=very satisfied analgesia)

  7. complication of the block

    Time frame: 24 hours

    complication of the block( heamatoma,local anesthetic toxicity,infection)

Study contacts

Contact information is provided by the study sponsor or research team.

Dina Salem, MD

CONTACT

01099333513 ext. 002

Marwa Medhat, MD

CONTACT

01002828937 ext. 002

Sponsors and collaborators

Lead sponsor

Zagazig University

Other Gov

Registry information

Official study title

Perioperative Opioid-sparing Effect of Retrosuperior Costotransverse Ligament Block Versus Erector Spinae Block in Laparoscopic Cholecystectomy: A Randomized Clinical Trial.

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 11, 2025
Registry last updated
Dec 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.