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NCT Number: NCT07197281

Perfusion Index and End Diastolic Velocity Ratios as Predictors of Supraclavicular Block Success in Vascular Access Surgery

This is a prospective observational study investigating the correlation between Perfusion Index (PI) ratio and End Diastolic Velocity (EDV) ratio as early predictors of successful supraclavicular brachial plexus block (SCBPB) in patients undergoing superficialization surgery of the upper limb.

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Key information

Conditions

End Diastolic Velocity Perfusion Index

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

About this study

Regional anesthesia is fundamental for upper limb surgeries, with SCBPB providing dense anesthesia. However, early confirmation of successful block performance remains challenging. Traditional clinical methods (sensory/motor testing) are subjective and delayed. This study proposes using objective, noninvasive indices - PI (evaluated via pulse oximetry) and EDV (measured by Doppler ultrasound) - to determine their accuracy in detecting sympathetic blockade shortly after SCBPB. Early and reliable detection of block success is particularly important in superficialization surgeries such as arteriovenous fistula (AVF) superficialization in patients with compromised vascular status. The results are expected to enhance anesthesia practice by providing quantitative, reproducible, and rapid assessment tools.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18-65 years

Both genders

ASA II-VI classification

Undergoing elective upper limb superficialization surgery (e.g., AVF superficialization)

Provided written informed consent

Exclusion criteria

  • Patient refusal

Coagulopathy or bleeding disorders

Local infection at injection site

Allergy to local anesthetics

Use of vasopressors or beta-blockers

Severe peripheral vascular disease

Morbid obesity (BMI > 35)

Severe neurological or psychiatric disorders

Treatment and study plan

Primary outcomes

  1. Change in Perfusion Index ratio

    Time frame: 15 minutes

    Change in Perfusion Index ratio at 15 minutes after supraclavicular brachial plexus block in predicting successful block

  2. Change in End Diastolic Velocity ratio

    Time frame: 15 minutes

    Change in End Diastolic Velocity ratio at 15 minutes after supraclavicular brachial plexus block in predicting successful block

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Correlation Between Perfusion Index Ratio and End Diastolic Velocity Ratio After Supraclavicular Brachial Plexus Block as an Early Predictor of Successful Block in Superficialization Surgery of the Upper Limb

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Sep 29, 2025
Registry last updated
Sep 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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