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NCT Number: NCT07637682

Percutaneous Neurostimulation in Knee Osteoarthritis

Peripheral nerve stimulation (PNS) is a drug-free pain management procedure that uses electrical impulses to target specific nerves and block pain signals. PNS helps decrease perception of pain, providing real answers to patients dealing with chronic knee pain. The case study discussed in this presentation is of the use of PNS targeting the superior lateral genicular nerve and the saphenous nerve for a patient with moderate to severe knee pain from osteoarthritis

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Key information

Conditions

Osteoarthritis (OA) of the Knee Arthritis Joint Diseases Musculoskeletal Diseases Neuromodulation Osteoarthritis Rheumatic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of medicine, Tanta University

Tanta, Egypt

Location status: Recruiting

Location contact

Aliaa Mamdouh Abdelaziz Farag, MD

CONTACT

[email protected]

+201069468486

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adults between the ages of 30 and 70 years with a clinical diagnosis of moderate to severe knee OA who suffered knee pain.
  • Patients who cannot afford intra-articular injections or radiofrequency ablation (RFA).
  • patients who had failed 2 different oral pain medications and 6 weeks of physical therapy.

Exclusion criteria

  • Patients with OA show improvement in pain after physiotherapy.
  • patients evaluated by an orthopaedic surgeon and deemed to be surgical candidates due to knee pathologies other than OA.
  • pregnant patients.
  • patients on anticoagulation therapy, who were not permitted to stop anticoagulation.
  • patients with previous trauma, neurological or endocrine diseases like diabetes mellitus, and knee tumors; and patients with inflammatory arthritis.
  • people who had received an intra-articular knee injection within the last 6 months.
  • Patients with tendon tears, bursitis, or calcified tendonitis as proven by imaging.

Treatment and study plan

nerve stimulation using a nerve stimulator to the genicular nerve

Device

temporary transcutaneous nerve stimulation using a nerve stimulator to the genicular nerve, with settings 2Hz, 0.2mA, 1ms, where the nerve is stimulated for 4 to 6 minutes.

nerve stimulation using a nerve stimulator to the saphenous nerve

Device

temporary transcutaneous nerve stimulation using a nerve stimulator to the saphenous nerve, with settings 2Hz, 0.2mA, 1ms, where the nerve is stimulated for 4 to 6 minutes.

Primary outcomes

  1. Change in visual analogue scale after intervention.

    Time frame: immediately after intervention.

    Decrement (clinical improvement) in visual analogue scale (VAS) immediately after intervention. The participant's knee discomfort was measured using a VAS. Participants were asked to score their level of pain on a 100-mm horizontal line, ranging from 0 to 100.

Study contacts

Contact information is provided by the study sponsor or research team.

Aliaa Mamdouh Abdelaziz Farag, MD

CONTACT

[email protected]

+201069468486

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Official study title

Percutaneous Peripheral Temporary Neurostimulation in Moderate to Severe Knee Osteoarthritis

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jun 10, 2026
Registry last updated
Jun 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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