Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses Renewal

The overall goal of this project is to develop modular, lower-limb, powered orthoses that fit to user-specific joints and control torque in a manner that enhances voluntary motion and mitigates musculoskeletal pain. Commercial exoskeletons typically use actuation and control methods that force the human user to follow specific, rigid gait patterns. This has prevented emerging wearable robotics from effectively addressing the weakness and pain associated with mild to moderate impairments, such as knee osteoarthritis (OA). These populations require partial, task-agnostic assistance that works harmoniously with their voluntary motion rather than constraining it.

To bridge this gap, this project utilizes a quasi-direct drive actuation paradigm, a high-torque motor combined with a low-ratio transmission, integrated into conventional knee stabilizer and unloader braces. This hardware is uniquely capable of producing large output torques without causing perceptible resistance when backdriven by the human joint. To control the device across various activities of daily living (ADLs) without requiring pre-programmed trajectories, the investigators are developing a neural network-based formulation of "energy shaping" (effectively combining virtual springs, dampers, and gravity/inertia compensation) trained on multi-activity human data.

The specific objectives of this study period are to:

• Integrate the modular quasi-direct drive actuator and miniaturized electronics into both a modified knee stabilizer brace and a modified unloader knee brace.
• Implement and validate the neural network-based energy shaping controller to provide task-agnostic, biomimetic torque assistance with able-bodied subjects.
• Establish the clinical feasibility of this technology in individuals with multi-compartment knee OA.

The investigators hypothesize that the biomimetic torque assistance provided by these motorized braces will significantly reduce quadriceps effort, knee joint moment loads, and subjective pain across ADLs.

Inclusion criteria

Inclusion criteria

for able-bodied, young participants will be:

• Aged between 18 to 65 years
• Weigh less than 300 lbs (due to challenges in bracing heavier participants)
• BMI < 40 (due to challenges in bracing heavier participants)

Inclusion criteria

for knee osteoarthritis participants will be:

• Aged between 30 to 85 years
• Medical diagnosis of patellofemoral and tibiofemoral osteoarthritis
• Patient reported pain ≥ 4 out of 10 during activities of daily life (to avoid floor effects)
• Weigh less than 300 lbs (due to challenges in bracing heavier participants)
• BMI < 40 (due to challenges in bracing heavier participants)
• Ability to walk 6 minutes without assistance from a person (may use walking aid)
• Ability to ascend/descend ramps and stairs with or without the use of handrails

Exclusion criteria

Exclusion criteria

for able-bodied, young adult participants will be:

• Pregnant (self-report)
• Any significant neuromuscular or musculoskeletal disorder that would interfere with the study
• Unable to walk for 20 minutes
• History of any cardiovascular, vestibular, or visual diseases and/or impairments that may interfere with the study
• Cognitive deficits that would impair their ability to give informed consent or impair their ability to follow simple instructions during the experiments. Cognitive deficits will be determined by a Mini-Mental State Examination (MMSE) score of <22.
• Adults with a known allergy to medical grade tape

Exclusion criteria

for knee osteoarthritis participants will be:

• Pregnant (self-report)
• Any recent lower-extremity fracture (within 6 months)
• Significant limitation on knee joint range of motion
• Significant neurological (e.g., stroke) or cardiovascular disorder that may affect the ability to walk
• Advised by a physician not to walk or exercise
• Uncontrolled hypertension or diabetes
• Use of opioids
• Cognitive deficits or visual impairment that would impair their ability to give informed consent or impair their ability to follow simple instructions during the experiments. Cognitive deficits will be determined by a Mini-Mental State Examination (MMSE) score of <22.
• Adults with a known allergy to medical grade tape