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OpenTrials
Completed

NCT Number: NCT03788031

Perceptual Learning Treatment for Amblyopia

Objectives. To develop a new treatment for amblyopia using a perceptual learning approach.

Hypothesis to be tested. Our proposed experiments are designed to investigate whether practicing a grating detection task can improve vision in patients with amblyopia.

Design and subjects. A total of 36 patients with amblyopia will be randomized allocated into two intervention groups: Group 1, perceptual learning therapy. Group 2, occlusion therapy. A control group comprising of 18 subjects with normal vision will be recruited for comparison. A battery of tests will be used to assess a range of visual functions before and after the treatment intervention.

Study instruments. Grating acuity testing system

Interventions. We have established a clinical protocol for acuity training. On each trial, a properly oriented stimulus will be presented randomly at one of the four locations on a flat monitor screen. The visual task is to indicate the location of the stimulus. Participants will be required to undertake 20 one-hour sessions of training.

Main outcome measures. Resolution acuity, visual acuity, contrast sensitivity function

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Key information

Conditions

Amblyopia Brain Diseases Central Nervous System Diseases Eye Diseases Nervous System Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Sensation Disorders Signs and Symptoms Vision Disorders

Age range

7 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Optometry Research Clinic

Hong Kong

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Visual acuity in the amblyopic eye: 20/25 or worse

Exclusion criteria

  • Manifest eye disease & nystagmus

Treatment and study plan

Acuity training

Other

The intervention will be a vision therapy. On each trial, a properly oriented stimulus will be presented randomly at one of the four locations on a flat monitor screen. The visual task is to identify the location of the stimulus.

Occlusion therapy

Other

Participants will be required to patch the good eye for 20 days, 1 hour per day.

Primary outcomes

  1. Change of grating acuity

    Time frame: 20 hours

    Grating acuity tests the participants' ability to resolve fine details. This study measures the change of grating acuity after 20 hours of vision training.

Secondary outcomes

  1. Change of visual acuity

    Time frame: 20 hours

    Visual acuity tests the participants' ability to resolve letters.This study measures the change of visual acuity after 20 hours of vision training.

  2. Change of contrast sensitivity

    Time frame: 20 hours

    Contrast sensitivity reflects the participants' sensitivity to identify low contrast visual stimuli. This study measures the change of contrast sensitivity after 20 hours of vision training.

  3. Change of stereopsis

    Time frame: 20 hours

    Visual acuity tests the 3-D perception. This study measures the change of stereopsis after 20 hours of vision training.

Sponsors and collaborators

Lead sponsor

The Hong Kong Polytechnic University

Other

Registry information

Official study title

Towards Developing a Perceptual Learning Treatment for Amblyopia

Important dates

Study start
2019
Primary completion
2022
Study completion
2023
First posted
Dec 27, 2018
Registry last updated
Aug 29, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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