Vision Therapy Outcomes in Amblyopia: Linking Brain Plasticity With Visual Perceptual Skills

The primary objective of this study is to evaluate the effects of a personalized vision therapy programme tailored to baseline visual-cognitive abilities in treatment-resistant amblyopia. In addition to testing the hypothesis that rehabilitation protocols targeting amblyopia related visual-perceptual and visual-cognitive skills. Spesific aims of this study are:

1. to identify which visual perceptual skills are most significantly impaired sen patients with amblyopia. 2. to evaluate whether interventions are targeting fundamental visual perceptual skills are associated with improvements in higher-order visual perceptual skills. 3. to determine whether vision therapy tailored to individual neuro-visual impairments associated with improvements in binocular function, including streopsis and overall visual perceptual performance. 4. to ases whether baseline neuro-visual perceptual performance predicts the response to vision therapy in patients with amblyopia.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Amblyopia Brain Diseases Central Nervous System Diseases Eye Diseases Nervous System Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Sensation Disorders Signs and Symptoms Vision Disorders

Age range

4 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Okan University

Istanbul, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Ambylopia patient
Minimal response to traditional treatments
Ages between 4-18
Receiving personalized vision therapy
Taking the TVPS-3 at least 2 times

Exclusion criteria

Responsive to treatment
Discontinued vision therapy

Treatment and study plan

Motor Free Perception Vision Test

Diagnostic Test

The Motor-Free Visual Perception Test-3 (MVPT-3) represents a significant methodological iteration in the assessment of non-motor visual processing, specifically validated for individuals ranging from 4 to 95 years of age. In pediatric and adolescent contexts (under 18), the MVPT-3 is utilized to isolate cognitive visual-perceptual skills-such as spatial relationships, visual discrimination, figure-ground, and visual closure-from fine motor coordination, which may still be developing or impaired. The test consists of 65 items arranged in a horizontal format to accommodate individuals with hemispatial neglect or limited field of vision. For younger examinees, the assessment is particularly vital for identifying perceptual deficits that may impede academic performance, such as reading fluency or mathematical reasoning, without the results being skewed by the child's handwriting or drawing abilities. By providing age-adjusted normative data, the MVPT-3 allows clinicians to derive standard

Primary outcomes

The Correlation Between Vision Therapy and Visual Cognitive Skills and It's Therapeutic Results in Amblyopia: Associating with Brain Plasticity and Visual Perceptual Skills

Time frame: From June 2024 to June 2025

Sponsors and collaborators

Lead sponsor

Okan University

Other

Registry information

Official study title

Correlation of Vision Therapy With Visual-Cognitive Skills and Therapeutic Outcomes in Amblyopia: Linking Brain Plasticity With Visual Perceptual Skills

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Feb 27, 2026
Registry last updated: Mar 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed