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Enrolling by Invitation

NCT Number: NCT07496489

Perceptions of Proposed Warnings for Cannabis Edibles Packaging

The purpose of this study is to compare a delayed-effects warning to an expanded warning developed in previous experiments on knowledge, harm perceptions, and willingness to try cannabis edibles. Additionally, this study will examine the effects of a corresponding icon on attention to and recall of the warning.

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Key information

Conditions

Cannabis Use Chemically-Induced Disorders Marijuana Abuse Mental Disorders Substance-Related Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States

About this study

Cannabis edibles are rapidly leading the legal recreational cannabis market. The Cannabis edibles present health harms that are not typical of smoked marijuana, including accidental overconsumption of high levels of THC. One effective way to communicate proper dosing and risks of overconsumptions is through package warnings. This experiment will assign participants to view real cannabis edibles packaging with one of four variations of warnings and a series of questions to assess knowledge, harm perceptions, and willingness to try the product shown. One group of participants will serve as the control and will see the same cannabis edibles packaging without a warning.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • English-speaking by self-selection
  • United States resident

Exclusion criteria

  • Already participated in a precursor project (IRB00104038, IRB000111438)
  • Eligible but demographic and user group strata have already been met

Treatment and study plan

No Warning Control

Behavioral

Participants in the control condition will see an edible cannabis package without a warning message.

Delayed Effects Text Only

Behavioral

Participants will see a cannabis edibles package with a warning message containing a delayed effects message.

Delayed Effects Plus Icon

Behavioral

Participants will see a cannabis edibles package with a warning containing a delayed effects message and a corresponding icon.

Delayed Effects Plus Dose

Behavioral

Participants will view a cannabis edibles package with a warning containing delayed effects message and dosing instructions.

Delayed Effects Plus Dose Plus Adverse Effects

Behavioral

Participants will view a cannabis edibles package with a warning containing delayed effects, dosing instructions, and adverse effects message.

Primary outcomes

  1. Product appeal score

    Time frame: Minute 1

    One item to assess the appeal of the product. Results will be reported as means.

    Question: How appealing is this edible to you? Response options: (0) Not at all appealing to (10) Very appealing. Higher score denoting more appeal

  2. Perception of product safety score

    Time frame: Minute 1

    One item to assess the participants' perception of the safety of the product. Results will be presented as the frequency of each type of response.

    Question: How safe do you think it would be to eat this edible? Response options: (1) Not at all safe, (2) Slightly safe, (3) Somewhat safe, (4) Moderately safe, (5) Very safe. Higher score denoting more safe to eat

  3. Perceived likelihood of experiencing unwanted effects score

    Time frame: Minute 1

    One item to assess the participants' perception of the likelihood of experiencing unwanted effects. Results will be presented as the frequency of each type of response.

    Question: How likely are you to experience unwanted effects if you eat this edible? Response options: (1) Not at all likely, (2) Slightly likely, (3) Somewhat likely, (4) Moderately likely, (5) Very likely. Higher score denoting greater likelihood of experiencing side effects

  4. Interest in a free sample score

    Time frame: Minute 1

    One item to assess how interested a participant would be in a free sample of the product. Results will be presented as the frequency of each type of response.

    Question: How interested would you be in a free sample of this edible? Response options: (1) Not at all interested, (2) Slightly interested, (3) Somewhat interested, (4) Moderately interested, (5) Very interested. Higher score denoting more interest

  5. Concern about the risks of overconsumption due to warning score

    Time frame: Minute 1

    One item to assess how much the warning makes the participant concerned about the risks of overconsumption for participants randomized to view a package with a warning (intervention conditions only). Results will be presented as the frequency of each type of response.

    Question: How much does this warning make you concerned about potential risks from eating too much of this edible? Response options: (1) Not at all, (2) A little, (3) Somewhat, (4) Quite a bit, (5) A great deal. Higher score denotes more concern

  6. Improved understanding of safe consumption due to warning score

    Time frame: Minute 1

    One item to assess how much the warning gives the participant a better understanding of how to safely consume an edible (intervention conditions only). Results will be presented as the frequency of each type of response.

    Question: How much does this warning give you a better understanding of how to safely consume this edible? Response options: (1) Not at all, (2) a little, (3) somewhat, (4) quite a bit, (5) a great deal. Higher score denotes better understanding of safety

Secondary outcomes

  1. Warning recall

    Time frame: Minute 1

    One item to assess the participant's recall of a warning message on the package. Results will be presented as the percentage correctly selected.

    Question: Do you recall seeing a warning on the package we showed you earlier? Response Options: Yes, No

  2. Attention Score

    Time frame: Minute 1

    One measure to assess the extent to which the warning grabbed the participant's attention. Asked of those who recall seeing a warning on the package. Results will be presented as frequency of each type of response.

    Question: How much did the warning grab your attention? Response options: (0) Not at all, (1) A little, (3) Somewhat, (4) A lot, Higher score denotes more attention

Sponsors and collaborators

Lead sponsor

Wake Forest University Health Sciences

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Perceptions of Proposed Warnings for Cannabis Edibles Packaging (Cannabis Edibles Aim 2 Experiment)

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 27, 2026
Registry last updated
May 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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