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Completed

NCT Number: NCT02862405

Perception of Objects and Natural Scenes in People With Vision Loss (ACTIVIS)

The loss of central vision causes difficulty not only in reading but also in faces recognition, and in particular in the identification of facial expression, objects or spaces. These visual deficits have been mainly studied in relation with reading, which is the main complaint of these kind of patients. However, there are not enough data regarding perception of objects and spaces in this population. Then, the objectives are to study the visual-spatial abilities in individuals with vision loss, and altered cognitive processes, (2) to develop clinics tools for early detection and quantification of visual-spatial deficits and (3)to understand the capacities of normal peripheral vision in order to test the possibility of potential training for use of peripheral vision when central vision is impaired by an ophthalmic pathology.

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Key information

Conditions

Vision Loss Eye Diseases Nervous System Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Sensation Disorders Signs and Symptoms Vision Disorders

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

cases:

  • Patients with eye disease causing loss of central or peripheral vision
  • French speakers
  • Age between 18 and 90 years old
  • Written consent
  • Health insurance

Inclusion criteria

controls:

  • Sex and age matched controls (+/- 5 years)
  • French speakers
  • Normal visual examination with visual acuity of min 9/10

Exclusion criteria

  • Psychiatric disease or neurological pathologies
  • Communication difficulties (deafness / mutism)
  • Drug treatment altering concentration
  • Mental deterioration with MMS <24
  • Alcoholism or addiction to drugs
  • Persons under guardianship

Treatment and study plan

vision tests

Other

Primary outcomes

  1. Comparison of performances in visual tests between different groups according to error rate

    Time frame: at inclusion

    These behavioral studies include a series of short tests of 5 to 10 minutes each (not exceeding 60 minutes with breaks and instructions) in which photos of scenes or isolated objects will be presented in central or peripheral vision using a computer screen or a panoramic screen covering a 180° field.

  2. Comparison of performances in visual tests between different groups according to answer time

    Time frame: at inclusion

    These behavioral studies include a series of short tests of 5 to 10 minutes each (not exceeding 60 minutes with breaks and instructions) in which photos of scenes or isolated objects will be presented in central or peripheral vision using a computer screen or a panoramic screen covering a 180° field.

Secondary outcomes

  1. Estimation of the score of visual acuity by the logMAR chart

    Time frame: at inclusion

  2. Measure of lesion size

    Time frame: at inclusion

  3. Pearson correlation coefficient to determine the correlation between the performance parameters during visual tests (error rate and answer time) and clinical parameters (visual acuity and lesion size)

    Time frame: at inclusion

    These behavioral studies include a series of short tests of 5 to 10 minutes each (not exceeding 60 minutes with breaks and instructions) in which photos of scenes or isolated objects will be presented in central or peripheral vision using a computer screen or a panoramic screen covering a 180° field.

Sponsors and collaborators

Lead sponsor

Lille Catholic University

Other

Collaborators

  • University Hospital, Lille

Registry information

Official study title

Evaluation of the Perception of Objects and Natural Scenes in People With Vision Loss (Loss of Central or Peripheral Vision)

Acronym: ACTIVIS

Important dates

Study start
2011
Primary completion
2015
Study completion
2015
First posted
Aug 11, 2016
Registry last updated
Aug 11, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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