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NCT Number: NCT06591741

PCA Administration in Prosthetic Joint Infection

Determine if dietary protocatechuic acid (PCA) will affect health biomarkers in patient undergoing revision surgery for a knee prosthetic joint infection

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Key information

Conditions

Prosthetic Joint Infection

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Patients who are scheduled to undergo revision surgery for a knee prosthetic joint infection are given PCA prior to surgery for a time period determined by a previous pilot study. PCA is then post-operatively until anticoagulation is stopped, and then will be resumed for four years post revision surgery. Measurement of changes in glucose control, immunity, will be measured over the first 3 months post-revision, and the post-revision reinfection rate over the full 4 years will be compared to a cohort rate

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 3 weeks or more after total knee arthroplasty
  • One or more symptoms of infection, including redness, swelling, pain, increasing range of motion loss, fever, nausea, and loss of appetite.
  • WBC count of aspirate >50,000 cells per μL

Exclusion criteria

  • Not willing to undergo blood draw at 3 months.

Treatment and study plan

Oral PCA

Dietary Supplement

PCA 1,000 mg BID until surgery, held until anticoagulation, and resumed at 1,000 mg daily for 4 years

Primary outcomes

  1. Change in immunity factor CXCL9 from 0 to 3 months

    Time frame: 0 and 3 months

  2. Change in HbA1c from 0 to 3 months

    Time frame: 0 and 3 months

Secondary outcomes

  1. Reinfection rate after revision for prosthetic joint infection

    Time frame: 0 to 4 years

Study contacts

Contact information is provided by the study sponsor or research team.

Kenneth D Reeves, M.D.

CONTACT

[email protected]

9139637750

Lanny Johnson, M.D.

CONTACT

[email protected]

5172851812

Sponsors and collaborators

Lead sponsor

Dr. Dean Reeves Clinic

Other

Collaborators

  • Lanny Johnson, M.D.
  • Leo Whiteside, M.D.

Registry information

Official study title

Effects of Dietary Protocatechuic Acid (PCA) on the Function and Structure of Participants With Knee Prosthetic Joint Infection (PJI) as Measured by Standard Biomarkers

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Sep 19, 2024
Registry last updated
Aug 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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