Patienthèque of Finisterian (South of Brittany) Children With Cystic Fibrosis in the Time of Precision Medicine

This is a monocentric study in 3 phases:

• Pre-inclusion: at the first visit to the CRCM (support for a positive screening confirmed by sweat test and genotyping CFTR)
• Inclusion: possible between the 2nd visit to the CRCM (about 2 months old) and the 6th month
• Follow-up: up to 36 months old. The pace of visits will be based on the usual follow-up rate of CF infants Clinical and paraclinical data and samples will be collected as part of the usual follow-up of CF children. Inclusions and follow-up visits will be carried out at the Roscoff CRCM as well as respiratory explorations and biological samples. Dermatological and odontological follow-ups will be scheduled for each patient at the rate of an annual visit to the CHRU in Brest in the relevant departments.

Inclusion criteria

• Newly screened infants with a confirmed diagnosis of cystic fibrosis in its classic form (clinical symptoms and two positive sweat tests and/or two mutations of the cftr gene from Class I to III)
• Children free of any colonization with P. aeruginosa
• Affiliation with the social security system
• Consent signed by the holders of parental authority or the sole parent holding parental authority

Exclusion criteria

• Children colonized with P. aeruginosa according to the cytobacteriological examination and / or molecular test of sputum or pharyngeal specimens
• Children grafted
• Children not affiliated to a social security scheme or not entitled to
• Children whose parent (s) are (are) minor (s)
• Children whose holders of parental authority do not master the French language
• Refusal to participate in the study