Pathogenic Study of Adult Immune Enteropathies

The study focuses the mechanisms underlying the loss of intestinal homeostasis in celiac disease, refractory celiac disease and other immune diseases such as monogenic enteropathy, inflammatory bowel diseases or drug induced intestinal diseases. Mechanisms of transformation of lymphocytes leading to onset of lymphomatous complications of immune enteropathies will be investigated. Mechanisms of loss of hepatic lymphocytic homeostasis will also be assessed in liver associated diseases.

Recruiting

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Key information

Conditions

Celiac Disease Autoimmune Enteropathy Congenital, Hereditary, and Neonatal Diseases and Abnormalities Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Genetic Diseases, Inborn Immune System Diseases Immunologic Deficiency Syndromes Inflammatory Bowel Diseases Intestinal Diseases Malabsorption Syndromes Metabolic Diseases Nutritional and Metabolic Diseases Primary Immunodeficiency Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hôpital Henri Mondor, Créteil, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

18 years or over
affiliated to social insurance
signed informed consent

Exclusion criteria

pregnancy
under guardianship
not able to sign informed consent

Treatment and study plan

Blood sample collection; gastrointestinal biopsy

Genetic

Targeted Next generation sequencing and whole exome sequencing Phenotyping of intestinal lymphocytes, single cell analyses, cytokines dosage...

Primary outcomes

Intestinal Lymphocytes count

Time frame: Baseline

Lymphocytes isolation
DNA sequencing

Time frame: Baseline

Targeted Next Generation sequencing

Study contacts

Contact information is provided by the study sponsor or research team.

Anaïs LEVESCOT, MD, PhD

CONTACT

[email protected]

33 1 42 75 42 77

Georgia MALAMUT, MD, PhD

CONTACT

[email protected]

33 1 58 41 41 76

Sponsors and collaborators

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Other Gov

Collaborators

Imagine Institute

Registry information

Acronym: ENTEROPATH

Important dates

Study start: 2020
Primary completion: 2030
Study completion: 2033
First posted: Feb 21, 2020
Registry last updated: Sep 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed