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NCT Number: NCT02917070

Parental Consanguinity and Family History of Kidney Disease in Turkish Kidney Disease Population

Inbreeding and consanguineous marriages are known to increase the risk of autosomal recessive disorders. The aim of this study was to examine the association between consanguinity and kidney diseases in the adult Turkish population.

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Key information

Conditions

Hereditary Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Istanbul University, Istanbul Faculty of Medicine

Istanbul, 34030, Turkey (Türkiye)

About this study

This was a national, cross-sectional study recruiting patients from nephrology out-patient clinics and dialysis units. All patients between 18 and 70 years of age who were on follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty from October 2009 to October 2015 were included in the study. All patients and healthy controls enrolled in this study gave informed consent to participate in the survey. They were all asked to answer a questionnaire including socio-demographic data, history of familial kidney disease and consanguineous marriage. Additional information was obtained from their private physicians and medical files. To ensure reliability of administration of the questionnaire, all interviewers underwent training using a standardized protocol.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty
  • between 18-70 years old
  • provide informed consent

Exclusion criteria

  • follow-up shorter than 6 months
  • patients whose data were not available
  • patients who were unwilling or unable to provide informed consent

Treatment and study plan

Patients

Other

In this study we aimed to investigate effect of family history and consanguineous marriage in the development of CKD in the adult Turkish population.

Other names: Inbreeding marriage

Primary outcomes

  1. Effect of parental consanguinity on chronic kidney disease confirmed by a questionnaire did they have consanguinity marriage or not.

    Time frame: 6 months after enrollment

Secondary outcomes

  1. Effect of family history of kidney disease on the development of chronic kidney confirmed by a questionnaire did they have any parents with chronic kidney diseases or not.

    Time frame: 6 months after enrollment

Sponsors and collaborators

Lead sponsor

Istanbul University

Other

Registry information

Official study title

The Importance of Parental Consanguinity and Family History of Kidney Disease in Turkish Adult Chronic Kidney Disease Population

Acronym: CAKD

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Sep 28, 2016
Registry last updated
Sep 28, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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