Pangenomic Study During Alcoholic Cirrhosis

Hepatocellular carcinoma (HCC) is a frequent complication of cirrhosis. Occurrence of HCC could be linked with multiple functional region of genome.

The determining of a genomic mapping of " single nucleotide polymorphisms " (SNPs) permit to perform some genetic link studies with pathologies without clear hereditary disposition.

In this study, the investigators will identify predictives genetic polymorphism of HCC.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Alcoholic Cirrhosis Alcohol-Induced Disorders Alcohol-Related Disorders Chemically-Induced Disorders Digestive System Diseases Fibrosis Liver Cirrhosis Liver Cirrhosis, Alcoholic Liver Diseases Liver Diseases, Alcoholic Pathologic Processes Pathological Conditions, Signs and Symptoms Substance-Related Disorders

Age range

35 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Nantes UH, Nantes, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

35 to 70 years old
Compensated cirrhosis or not
Caucasian origin of the parents
Patient with cirrhosis (histological proof or obvious)

Exclusion criteria

HIV, HBV, HCV positive
Known Homozygotia (C282Y+/+)
Important hepatocytary iron overload for patient with resection
HCC non histologically prooved

Treatment and study plan

DNA extraction

Genetic

DNA extraction of blood sample for DNAship analysis

Primary outcomes

Existence of HCC and Pangenomic analysis of DNA polymorphism

Existence of HCC and determination of which genetic polymorphism are predisposing to HCC or preventing for HCC

Secondary outcomes

cirrhosis severity (compensated or not)

Analysis of the genetic polymorphism involved in the severity of cirrhosis

Sponsors and collaborators

Lead sponsor

Nantes University Hospital

Other

Registry information

Official study title

Genetical Predisposition in Hepatocellular Carcinoma : Pangenomic Link Study During Alcoholic Cirrhosis

Acronym: CDCHC

Important dates

Study start: 2008
Primary completion: 2011
Study completion: 2013
First posted: Feb 9, 2010
Registry last updated: Sep 17, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed