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NCT Number: NCT05606211

Pain in Long COVID-19: the Role of Sleep

Pain is among the most frequently reported symptoms in Long COVID, along with sleep disturbances, fatigue, and cognitive impairments. Sleep plays a critical role in maintaining a pain-free state. The goal of this study is to characterize the type and severity of pain in Long COVID, to characterize sleep and sleep disturbances in Long COVID, and to understand the role of sleep in the development and persistence of pain symptoms in Long COVID.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Long COVID COVID-19 Chronic Disease Coronaviridae Infections Coronavirus Infections Disease Attributes Infections Lung Diseases Nidovirales Infections Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Pneumonia, Viral Post-Acute COVID-19 Syndrome Post-Infectious Disorders RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Females and males >18 years
  • Confirmed history of SARS-CoV-2 infection

Exclusion criteria

  • History of chronic pain prior to SARS-CoV-2 infection
  • Raynaud syndrome
  • Pregnant/nursing

Treatment and study plan

No intervention

Other

Observational, no intervention

Primary outcomes

  1. Pain reporting

    Time frame: 14 days

    Daily pain severity reporting on rating scale from 0 to 10 (greater values indicate greater pain)

  2. Pain sensitivity

    Time frame: 1 day

    Pain thresholds to mechanical and temperature stimuli measured in kPa (pressure) and Celsius (heat). Lower values indicate lower pain thresholds.

  3. Central pain modulation

    Time frame: 1 day

    Capacity of the CNS to modulate pain

  4. Wearable based sleep characteristics

    Time frame: 2 weeks

    Estimation of sleep duration, fragmentation, regularity based on actigraphy

  5. PSG based sleep characteristics

    Time frame: 1 day

    Sleep stages and architecture based on PSG

Sponsors and collaborators

Lead sponsor

Beth Israel Deaconess Medical Center

Other

Registry information

Official study title

Pain in PASC - the Role of Sleep Disturbances

Important dates

Study start
2022
Primary completion
2025
Study completion
2025
First posted
Nov 4, 2022
Registry last updated
Mar 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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