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Active, Not Recruiting

NCT Number: NCT05705648

Nutritional Management of Post COVID-19 Cognitive Symptoms

The goal of this clinical trial is to learn about in brain "fog" complaints associated with long-COVID in people aged 22-50-years. The main questions it aims to answer are:

* the natural course of brain "fog" complaints * the effect, if any of supplemental dietary oil on brain "fog" complaints Participants will be asked to undergo some brain testing (X-rays and questions. Treatments they'll be given will be one of two supplemental oils to consume daily.

Researchers will compare outcomes in the two different oil groups to see if it has any effect on brain "fog" complaints.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Long COVID Behavior Behavioral Symptoms COVID-19 Chronic Disease Confusion Coronaviridae Infections Coronavirus Infections Disease Attributes Fatigue Infections Lung Diseases Memory Disorders Mental Fatigue Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Nidovirales Infections Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Pneumonia, Viral Post-Acute COVID-19 Syndrome Post-Infectious Disorders RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Signs and Symptoms Virus Diseases

Age range

22 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Alberta

Edmonton, Alberta, T6G 2P4, Canada

About this study

Randomized placebo-control clinical trial comparing two types of nutritional oil and evaluating the impact, if any, on subjective complaints of long-COVID cognitive changes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • confirmed COVID infection, at least 3 months previously, with ongoing cognitive complaints
  • all other medical conditions stable, and on stable doses of medications (if required)

Exclusion criteria

  • COVID infection not confirmed by PCR or Rapid test
  • unable to speak English
  • pre-COVID cognitve complaints, and/or medical diagnoses affecting cognitive function

Treatment and study plan

Medium Chain Triglyceride oil

Dietary Supplement

Medium chain triglyceride oil

Safflower oil

Dietary Supplement

Safflower oil

Primary outcomes

  1. Cognigram(R)

    Time frame: 12-months

    computer-based cognitive test

Secondary outcomes

  1. Montreal Cognitive Assessment

    Time frame: 12-months

    Cognitive test

Sponsors and collaborators

Lead sponsor

University of Alberta

Other

Registry information

Important dates

Study start
2023
Primary completion
2026
Study completion
2027
First posted
Jan 31, 2023
Registry last updated
Jul 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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