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OpenTrials
Completed

NCT Number: NCT00983918

Pain After Laparoscopic Cholecystectomy

To the investigators' knowledge, no study has looked at differences in postoperative pain when comparing maintenance of anesthesia with isoflurane, desflurane, sevoflurane, and propofol in laparoscopic cholecystectomy. The investigators' hypothesis is that total intravenous anesthesia with propofol will lead to less postoperative pain in the first 24 hours after laparoscopic cholecystectomy when compared to maintenance of anesthesia with isoflurane, desflurane or sevoflurane.

PURPOSE

To find out if maintenance of anesthesia with propofol leads to less postoperative pain after laparoscopic cholecystectomy when compared to maintenance of anesthesia with isoflurane, desflurane, or sevoflurane.

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Key information

Conditions

Postoperative Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–64 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ben Taub General Hospital

Houston, Texas, 77030, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient ages 18-64
  • American Society of Anesthesiology Physical Status I, II or III
  • Inpatients scheduled to undergo laparoscopic cholecystectomy at Ben Taub General Hospital

Exclusion criteria

  • Open cholecystectomy - excluded due to increased levels of pain in open procedures
  • Scheduled for ambulatory surgery
  • Renal dysfunction (Serum Cr > 1.2) - excluded due to potential altered metabolism of anesthetic and pain medications
  • Allergy to any of the study medications or anesthetic agents
  • Chronic opioid analgesic use at home - excluded due to potential difficulty in assessing pain caused by the procedure alone
  • Patient inability to properly describe postoperative pain to investigators (language barrier, dementia, delirium, psychiatric disorder)
  • Patient or surgeon refusal

Treatment and study plan

Desflurane

Drug

Patient induced for general anesthesia as per standard protocol and maintenance of anesthesia provided with Desflurane

Sevoflurane

Drug

Patient induced for general anesthesia as per standard protocol and maintenance of anesthesia provided with Sevoflurane

Isoflurane

Drug

Patient induced for general anesthesia as per standard protocol and maintenance of anesthesia provided with Isoflurane

Propofol

Drug

Patient induced for general anesthesia as per standard protocol and maintenance of anesthesia provided with intravenous Propofol infusion

Primary outcomes

  1. Pain Measured on Verbal Scale of 0-10

    Time frame: 24 hours

    Pain measured on verbal scale of 0-10, with 0 being absolutely no pain, and 10 being the worst pain in that subjects life.

Sponsors and collaborators

Lead sponsor

Baylor College of Medicine

Other

Registry information

Official study title

Postoperative Pain After Laparoscopic Cholecystectomy After Anesthesia With Isoflurane, Desflurane, Sevoflurane or Propofol

Important dates

Study start
2009
Primary completion
2010
Study completion
2010
First posted
Sep 24, 2009
Registry last updated
Feb 1, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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