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Completed

NCT Number: NCT01673399

Oxytocin Antagonist in Patients With Repeated Failure of Implantation

In this study the investigators compare the usual way of embryo transfer (without medication) with an embryo transfer while administering oxytocine antagonist. This to improve implantation and increase the pregnancy rate.

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Key information

Conditions

Implantation Failure

Age range

18 year–38 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

AZ Jan Palfijn

Ghent, Oost-vlaanderen, 9000, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • IVF/ ICSI patients below 38 years
  • 2e to 6e IVF-cycle

Exclusion criteria

  • patients with endocrinological diseases or problems

Treatment and study plan

Atosiban

Drug

Bolus atosiban 6.75mg + infusion atosiban 18mg/u during 3 hours. once administered starting 1 hour before embryotransfer.

Placebo

Drug

Primary outcomes

  1. implantation rate

    Time frame: 16 days from eggretrieval

    the number of patients that show a positive serum blood pregnancy test

Secondary outcomes

  1. pregnancy rate

    Time frame: 12 weeks

    The number of patients with an ongoing first trimester pregnancy

Sponsors and collaborators

Lead sponsor

AZ Jan Palfijn Gent

Other

Collaborators

  • Onze Lieve Vrouw Hospital

Registry information

Official study title

Oxytocin Antagonist in Patients With Repeated Failure of Implantation. A Prospective Randomized Placebo-controlled Double-blind Study.

Important dates

Study start
2012
Primary completion
2015
Study completion
2015
First posted
Aug 28, 2012
Registry last updated
Feb 2, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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