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Completed

NCT Number: NCT07462754

Effect of Fire-Needle Combined With Regular Acupuncture on Pregnancy Outcome in Patients With Recurrent Implantation Failure Undergoing In Vitro Fertilization

This study aims to evaluate whether fire-needle combined with regular acupuncture improves pregnancy outcomes in patients with recurrent implantation failure (RIF), compared to no or regular acupuncture.

A retrospective cohort study was conducted at a university-affiliated hospital. One hundred RIF patients undergoing embryo transfer between July 2024 and June 2025 were assigned to three groups: a non-acupuncture group, a regular acupuncture group, and a fire needle combination group (receiving both fire needle and regular acupuncture).

Key outcome measures, including the β-hCG positive rate, clinical pregnancy rate (CPR), and miscarriage rate (MR), were compared among the three groups.

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Key information

Conditions

Implantation Failure

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, 430030, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • (1)18 ≤age ≤40 years; (2) ≥2 previous failures of high-quality embryo transfer without clinical pregnancy

Exclusion criteria

  • (1) preimplantation genetic testing cycles; (2) use of donor oocytes; (3) missing key data on treatment or outcome

Treatment and study plan

No acupuncture

Other

no acupuncture

regular acupuncture

Device

Regular acupuncture

Fire needle combination group

Device

fire needle combination group (receiving both fire needle and regular acupuncture)

Primary outcomes

  1. β-hCG-positive pregnancy

    Time frame: 1 year

    Test for hCG in the blood day 14 post-transfer

  2. Clinical pregnancy

    Time frame: 1 year

    ultrasonographic detection of an intrauterine gestational sac following embryo transfer

  3. Miscarriage

    Time frame: 1 year

    defined as spontaneous pregnancy loss occurring after ultrasound-confirmed clinical pregnancy

Sponsors and collaborators

Lead sponsor

Huazhong University of Science and Technology

Other

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Mar 10, 2026
Registry last updated
Mar 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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