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OpenTrials
Completed

NCT Number: NCT00200252

Oxytocin Administration in the Third Stage of Labour - A Study of Appropriate Route and Dose

Mothers are given the medication oxytocin after birth to help the uterus (womb) contract and therefore reduce blood loss. In Canada, oxytocin is given either into the muscle of the thigh or into a vein. However, it is not known which route is better.This study will test which dose and route of oxytocin is best in reducing blood loss following vaginal delivery.

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Key information

Conditions

Third Stage of Labour Hemorrhage Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

19 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Women's Health Centre, Eastern Health

St. John's, Newfoundland and Labrador, A1B 3V6, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • women 19 years and older
  • singleton pregnancy
  • 32 weeks gestation
  • spontaneous vaginal delivery

Exclusion criteria

  • previous postpartum hemorrhage
  • placenta previa
  • grand multiparity (>4)
  • anticoagulation therapy
  • delivery prior to 32 weeks gestation
  • operative vaginal delivery
  • antepartum hemorrhage > 20 weeks
  • hemoglobin <10g/dL
  • multiple gestation
  • intrauterine death

Treatment and study plan

Oxytocin

Drug

Primary outcomes

  1. change in hematocrit

Secondary outcomes

  1. estimated blood loss

  2. postpartum hemorrhage (estimated blood loss > 500cc)

  3. severe postpartum hemorrhage (estimated blood loss > 1000cc)

  4. incidence of hypotension

  5. length of third stage of labour

  6. need for blood transfusion

  7. incidence of retained placenta

  8. need for dilatation and curettage

  9. need for hysterectomy

  10. need for additional oxytocics after delivery

  11. postpartum antibiotic use

  12. maternal satisfaction

  13. bleeding needing readmission

Sponsors and collaborators

Lead sponsor

Memorial University of Newfoundland

Other

Registry information

Official study title

Intramuscular Versus Intravascular Oxytocin for the Third Stage of Labour

Important dates

Study start
2005
Study completion
2007
First posted
Sep 20, 2005
Registry last updated
Nov 9, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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