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OpenTrials
Completed

NCT Number: NCT06095518

DIC Markers and Thrombin Generation Parameters in Patients on ECMO Support: a Pilot Study

To study the correlation between novel DIC markers and thrombin generation parameters with thrombotic and hemorrhagic complications of patients on ECMO support.

Completed

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Key information

Conditions

Extracorporeal Circulation; Complications Cardiovascular Diseases Embolism and Thrombosis Extracorporeal Membrane Oxygenation Complication Hemorrhage Pathologic Processes Pathological Conditions, Signs and Symptoms Thrombosis Vascular Diseases

Age range

Up to 80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Queen Mary Hospital

Hong Kong

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≧ 18; AND
  • Admitted to the mixed medical-surgical intensive care units of Queen Mary Hospital or Tuen Mun Hospital in Hong Kong; AND
  • Require either veno-arterial (VA) or veno-venous (VV) extracorporeal membrane oxygenation (ECMO) support.

Exclusion criteria

  • Patients who are on central VA-ECMO support; OR
  • Patients with missing clinical data; OR
  • Patients with pre-existing thromboembolism requiring long term anticoagulation prior to ECMO cannulation; OR
  • Post-operative admissions

Treatment and study plan

DIC markers and Thrombin Generation Parameters

Diagnostic Test

Observation of DIC markers and thrombin generation parameters in patients with and without thrombotic and hemorrhagic complications

Primary outcomes

  1. Composite of thrombotic and hemorrhagic events

    Time frame: From the start of ECMO support to the end of ECMO support (which can be variable, typically around 5 days to 1 week)

    Thrombotic events include circuit-related thrombosis (e.g. oxygenator failure requiring circuit change) OR Non-circuit-related thrombosis (e.g. new pulmonary embolism or deep vein thrombosis while on ECMO.

    Hemorrhagic events include bleeding at critical sites or requiring interventions.

Sponsors and collaborators

Lead sponsor

Queen Mary Hospital, Hong Kong

Other

Registry information

Acronym: DIC-ECMO

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Oct 23, 2023
Registry last updated
Jul 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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