Outcome of Women With Cervical Cancer

Squamous cell carcinoma (SCC) of the cervix has showed a marked decline in developed countries over the past 40 years, however, there has also been an increase in relative and absolute incidence of adenocarcinoma and adenosquamous carcinoma (AC) of the uterine cervix over the same period.

Our understanding of the natural history and optimal management of AC is limited. It appears that AC and SCC of the cervix behave differently. They are different in epidemiology, prognostic factors, and patterns of failure after similar treatments. Available data suggest that they may also differ in their response to treatment. We postulate that new treatment strategies specifically tailored to AC should be explored.

However, there is few data about outcome of cervical cancer in Taiwan. So we propose this proposal for retrospective analysis of clinicopathological parameters and outcomes in patients of cervical cancer, especially for cervical adenocarcinoma and adenosquamous carcinoma.

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Key information

Conditions

Cervical Cancer Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Neoplasms Neoplasms by Site Urogenital Diseases Urogenital Neoplasms Uterine Cervical Diseases Uterine Cervical Neoplasms Uterine Diseases Uterine Neoplasms

Age range

20 year–99 year

Sex eligibility

Female

Study type

Observational

Primary location

Far Eastern Memorial Hospital

Banqiao District, Taipei, 22050, Taiwan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Time interval: from 1991 to date.
Comprehensive surgical staging, debulking procedure, radiotherapy or chemotherapy.
All female patients with cervical cancer who underwent treatment for cervical cancer at Far Eastern Memorial Hospital.
All the patients diagnosed as cervical cancer, especially for women with adeno- and adenosquamous carcinoma.
To review:

Clinical data: including age at diagnosis, presenting symptoms, gravidity, parity, menstrual history, body mass index, history of diabetes, hypertension, personal history of cancer and staging.
Pathologic information: deep stromal invasion, lymph-vascular space invasion, lymph node involvement, parametrium invasion, vaginal cut end and tumor size.
Survival data: disease-free and overall survival.
Radiation report, Chemotherapy treatment, operation, discharge and admission note.

Exclusion criteria

Not comprehensive staging/debulking procedure.
Patients who died of postoperative complications within 30 days after surgery were excluded from the survival analysis.
Female minors or disabled persons.

Treatment and study plan

Primary outcomes

Outcome of women with cervical cancer

Time frame: 20 years

Sponsors and collaborators

Lead sponsor

Far Eastern Memorial Hospital

Other

Registry information

Important dates

Study start: 2014
Primary completion: 2015
Study completion: 2016
First posted: Jan 3, 2014
Registry last updated: Sep 7, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed