Skip to main content
OpenTrials
Recruiting

NCT Number: NCT02771496

Osteochondritis Dissecans of Knee Prospective Cohort

The Cohort is a multi-site prospective data collection study that will enroll any patient with diagnosis of knee OCD (confirmed by a standard of care x-ray or MRI). Patients will be followed for up to the next 50 years of their lives to study courses of care, disease progression, treatment/surgical options/results, and specific sports-related outcomes in athletic patients. Subjects will complete quality of life surveys as part of the Cohort. Course of care will not be affected.

Recruiting

Interested in participating?

Request Info

Key information

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location status: Recruiting

Location contact

James L Carey, MD

PRINCIPAL_INVESTIGATOR

Mounika Ponakala, BS

CONTACT

[email protected]

About this study

Patients will be recruited and consented at the visit in which their eligibility is determined. Once a patient is eligible and provides informed consent, he or she will be in the study for up to 50 years, or until his or her OCD lesion is healed successfully.

At the initial visit, a subject will complete a basic medical history form, and three questionnaires: the IKDC Subjective questionnaire (ages over 18) or the PEDI-IKDC Subjective questionnaire (ages under 18); the KOOS questionnaire; and the Marx Activity Scale (adult) or Pedi-FABS Scale (pediatric). Patients will then continue with their normal course of care as determined by their surgeon and care team.

Mandatory surveys (same as above) will be collected from patients at 2 years, 5 years, 10 years, and 25 years. Patients who cannot return to clinic will have the option to complete the assessments and return in pre-stamped and addressed return envelopes provided by the clinical site the subject is a patient at. Any other follow-up visits between these time intervals will also be options for patients to complete these assessments, however patients will not complete them any closer than intervals 12 weeks apart in order to prevent redundancy.

Additionally, at the initial visit, the surgeon will complete a routine patient history and physical exam, which will be collected. Any surgical procedures or physical therapy a patient undergoes for treatment of his or her OCD lesion will also be documented and collected. At follow-up visits, surgeons will complete their own physical exam follow-up assessment forms, which will be collected.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of osteochondritis dissecans or focal articular cartilage defects as confirmed by x-ray or MRI

Exclusion criteria

  • Non-confirmed diagnosis (i.e. patient does not yet have imaging confirmation)

Treatment and study plan

Other: observational only- no intervention

Other

Other: observational only- no intervention

Primary outcomes

  1. IKDC questionnaire

    Time frame: baseline up to 50 years

    The primary outcome endpoint for this study is the patient's score on the IKDC Subjective questionnaire, or PEDI-IKDC Subjective questionnaire for patients under 18 years of age.

  2. PEDI-IKDC questionnaire

    Time frame: baseline up to 50 years

    The primary outcome endpoint for this study is the patient's score on the IKDC Subjective questionnaire, or PEDI-IKDC Subjective questionnaire for patients under 18 years of age.

Secondary outcomes

  1. KOOS Knee score

    Time frame: baseline up to 50 years

    The Knee injury and Osteoarthritis Outcome Score (KOOS) evaluates short-term and long-term symptoms and function in subjects with knee injury and osteoarthritis.

  2. Marx Activity Score questionnaire

    Time frame: baseline up to 50 years

    Measure of physical activity at healthiest and most active state from time of taking to year prior.

  3. Pedi-FABS Score

    Time frame: baseline up to 50 years

    An eight-item scale that measures level of physical activity and fitness.

  4. Radiographic Healing

    Time frame: baseline up to 50 years

    Visualization of bone healing through x-ray images.

Study contacts

Contact information is provided by the study sponsor or research team.

Mounika Ponakala, MS

CONTACT

[email protected]

6093343767

Sponsors and collaborators

Lead sponsor

University of Pennsylvania

Other

Collaborators

  • Altona Children's Hospital
  • Boston Children's Hospital
  • Children's Health Andrews Institute for Orthopaedics & Sports Medicine
  • Children's Healthcare of Atlanta
  • Children's Hospital Colorado
  • Children's Hospital Medical Center, Cincinnati
  • Children's Hospital and Health System Foundation, Wisconsin
  • Children's Hospital of Philadelphia
  • Children's Mercy Hospital Kansas City
  • Connecticut Children's Medical Center
  • Göteborg University
  • Hospital for Special Surgery, New York
  • Kaiser Permanente
  • Mayo Clinic
  • National University Hospital, Singapore
  • Rady Children's Hospital, San Diego
  • Stanford University
  • Tennessee Orthopedic Alliance
  • Texas Scottish Rite Hospital for Children
  • The Hospital for Sick Children
  • The Rocky Mountain Hospital for Children
  • University of Minnesota/TRIA Orthopaedic Center
  • Washington University School of Medicine

Registry information

Official study title

ROCK Comprehensive Prospective Cohort for Osteochondritis Dissecans of the Knee

Important dates

Study start
2014
Primary completion
2074
Study completion
2074
First posted
May 13, 2016
Registry last updated
May 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.