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OpenTrials
Completed

NCT Number: NCT00104312

Osteoarthritis: Weakness From Inflammation

The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.

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Key information

Conditions

Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis, Knee Rheumatic Diseases

Age range

50 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Harbor Hospital

Baltimore, Maryland, 21225, United States

About this study

Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure.

This study requires 1 four-hour visit to Harbor Hospital. The visit involves a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be collected during your planned surgery.

Participation in this study is entirely voluntary.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 50 years of age or older
  • Normal body weight (a Body Mass Index (BMI) of 30 or less)
  • Osteoarthritis of the knee (prior to knee surgery)
  • Planning to have knee surgery at a MedStar Hospital

Exclusion criteria

  • History of a stroke
  • History of muscle weakness or paralysis
  • History of Rheumatoid Arthritis or
  • Inflammatory Joint Disease
  • History of a Bleeding Disorder
  • History of Gout
  • Diabetes for which you take insulin
  • Polymyalgia rheumatica (total body muscle aching/stiffness)

Sponsors and collaborators

Lead sponsor

National Institute on Aging (NIA)

Nih

Registry information

Official study title

Weakness From Inflammation: A Basis of Disability From Knee Osteoarthritis

Important dates

Study start
2001
Primary completion
2009
Study completion
2009
First posted
Feb 25, 2005
Registry last updated
May 29, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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