Oral Sodium Blood Pressure in Normal Weight, Overweight and Obese Volunteers

The primary objective of this study is to analyze the sensitivity of blood pressure to oral salt intake. Matched male and female participants will be selected as normal weight, overweight, and obese.

Participating subjects will have a first visit with blood pressure measurement and a blood sample. In two consecutive phases of one week, subjects will receive 12 pills of sodium (6 grams) or corresponding placebo. Blood pressure will be measured at the end of each phase.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

6 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Poitiers University Hospital

Poitiers, 86021, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Informed consent
Age 18-45 for adults and 6-8 for children

Exclusion criteria

African ethnicity (known to affect blood pressure sensitivity to salt)
Chronic condition affecting blood pressure
Diabetes (known to affect blood pressure sensitivity to salt)
Hypertension

Treatment and study plan

Sodium Chloride

Other

sodium chloride 500mg

Methylcellulose crystalline

Other

Methylcellulose 37 ml

Sponsors and collaborators

Lead sponsor

Poitiers University Hospital

Other

Registry information

Official study title

Simplification of the Test of Sensibility in the Salt: Preliminary Study at the Child and the Adult

Acronym: PLADSEL

Important dates

Study start: 2011
Primary completion: 2014
First posted: Feb 14, 2012
Registry last updated: Oct 11, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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