Oral Immunotherapy With Egg in Infants

In children allergic to egg, oral immunotherapy (OIT) with egg may accelerate that the children grow out of the food allergy.

Children than have a positive oral food provocation with egg with a low threshold, will be offered to start OIT. This means that the child have to ingest a small amount of egg every day.

Once a year, the child will undergo a new oral food provocation to investigate if the child is still allergic to egg or not.

The age of the children at time of this acquired tolerance will be compared with a historical cohort of children with egg allergy.

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Key information

Conditions

Food Allergy in Infants

Age range

12 month–36 month

Sex eligibility

All sexes

Study type

Observational

About this study

The aim of the study is to investigate if OIT with egg white can accelerate tolerance to egg in infants with provocation-verified allergy to egg and with a low threshold.

The study is non-randomised. Children fulfilling the inclusion criteria will be offered OIT. The children will undergo an oral provocation once a year to detect development of tolerance to egg. Age at tolerance acquisition will be compared with a histical cohort of aged-matched children with allergy to egg and with a similar threshold at the diagnostic provocation

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

positive specific IgE to egg
positive oral provocation for egg
low threshold

Exclusion criteria

uncontrolled astham treatment with biologics or immunsupressive drugs treatment with antihistamines

Treatment and study plan

low-dose OIT egg

Other

The children have to ingest a small specified amount of egg white every day. The amount will gradually increase, as the child becomes more and more tolerant to egg

Primary outcomes

Percentage of children who develops tolerance to egg per year

Time frame: If the oral food provocation is negative (that is the child is still allergic to egg) the child will be re-provocated after 12 months. As long as the provocation is positive it will be repeated once a year for 5 years

Once a year the children will undergo an oral food provocation with egg to investigate if they have becomed tolerant to egg

Secondary outcomes

specific IgE

Time frame: baseline and through study completion, an average of 1 year

Measurement of specific IgE to egg in the blood

Study contacts

Contact information is provided by the study sponsor or research team.

Josefine Gradman, MD, PhD

CONTACT

[email protected]

+4529241375

Sponsors and collaborators

Lead sponsor

Josefine Gradman

Other

Registry information

Official study title

Oral Immunotherapy With Egg

Acronym: OIT egg

Important dates

Study start: 2026
Primary completion: 2036
Study completion: 2036
First posted: Apr 20, 2026
Registry last updated: Apr 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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