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OpenTrials
Completed

NCT Number: NCT02986386

Oral Health for Healthy Cognitive Aging

Oral health is a critical factor of systemic health, although usually forgotten. A potential relation between cognitive deficits and oral diseases has been suggested. Adult cognitive dysfunctions have a high impact, not only economic, but social and in the family environment. Based on anatomical connectivity between the oral cavity and the central nervous system, the proposed study hypothesizes that masticatory function is a relevant determinant of human cognitive health. The restoration of canonical masticatory function and masticatory training could help to delay the development of such conditions. This project will also test if restoring phasic masticatory function improves the execution of cognitive tasks.

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Key information

Conditions

Malocclusion Behavior Bites and Stings Brain Diseases Central Nervous System Diseases Chemically-Induced Disorders Dementia Mental Disorders Nervous System Diseases Neurocognitive Disorders Personal Satisfaction Poisoning Psychological Well-Being Stomatognathic Diseases Tooth Diseases Wounds and Injuries

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Facultad de Odontología

Granada, 18071, Spain

About this study

Objective 1: To determine volumetric and anatomical changes of subcortical structures and cortical areas involved in the masticatory circuit and superior cognitive functions.

Objective 2: To determine the functional and brain connectivity changes associated with malocclusion and oral health.

Objective 3: To correlate the anatomic and functional changes associated with malocclusion and oral health with the performance of cognitive tasks representative of those executed in daily life.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • For Dental occlusion restoration groups: Need of, at least, two molar teeth replacement in the same quadrant.
  • For Orthodontic treatment of malocclusion groups: Class I, II or III malocclusion.

Exclusion criteria

  • Psychoactive drug.
  • Central nervous system depressor.
  • Patients not willing or not able to consent.

Treatment and study plan

Dental occlusion restoration

Procedure

Placement of dental implants by surgical intervention followed, after a healing period of 2 months, by fabrication and installation of implant supported dental prosthesis

Orthodontic treatment of malocclusion

Procedure

Orthodontic therapy to treat malocclusion

Primary outcomes

  1. Change of occlusion units

    Time frame: Baseline, 6, 12 and 36 months

    Number of teeth occluding with opposing teeth

  2. Change of cerebral activity

    Time frame: Baseline, 6, 12 and 36 months

    Functional MRI

  3. Change of cognitive function

    Time frame: Baseline, 6, 12 and 36 months

    Verbal fluency

  4. Change of frame of mind

    Time frame: Baseline, 6, 12 and 36 months

    Beck test

  5. Change of resting brain activity

    Time frame: Baseline, 6, 12 and 36 months

    Electroencephalographic activity

Sponsors and collaborators

Lead sponsor

Universidad de Granada

Other

Registry information

Acronym: SOECS

Important dates

Study start
2016
Primary completion
2023
Study completion
2025
First posted
Dec 8, 2016
Registry last updated
May 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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