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OpenTrials
Completed

NCT Number: NCT00604916

Oral Care Protocol for Preventing Ventilator- Associated Pneumonia

The Nosocomial Pneumonia remains to be a major complication for patients who were incubated with ventilation. Most cases are attributed to increased bacteria flora in oropharyngeal secretion and aspiration of those organisms. Research indicates that the Gram-Negative Bacteria grows in upper air way and trachea rapidly during the initial 2-4 hospital days and the dental plague also increased dramatically at the first 5 days. About 50% cases with prolonged intubation experienced temporal swallowing disorders and majority of them recovered 7 days post weaning. Some evidence exist suggesting that oral care could reduce bacterial flora, prevent aspiration, and subsequently decrease the incidence of ventilation-associated pneumonia for this group of high risk patients.

This study aims to evaluate the effectiveness of a standardized oral care protocol in improving oral hygiene and reducing the incidence of pneumonia on a sample of surgical patients at intensive care unit.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients newly admitted to SICU who were under ventilator support for 48~72 hours

Exclusion criteria

  • With pneumonia present

Treatment and study plan

standardized oral care protocol - electronic toothbrush

Other

a standardized 20-minute oral care protocol using an electronic toothbrush to clean and moisturize oral cavity twice daily.

mimic protocol

Other

a mimic 20-minute protocol involving moisturizing and attention control was performed for the same intervals.

Primary outcomes

  1. the oral hygiene status measured by the oral assessment guide and plague index

    Time frame: every 3~4days

Secondary outcomes

  1. The incidence of VAP defined by the Clinical Pulmonary Infection Score

    Time frame: a 7 day oral care protocol duration

Sponsors and collaborators

Lead sponsor

Mackay Memorial Hospital

Other

Collaborators

  • National Taiwan University

Registry information

Official study title

The Effectiveness of an Oral Care Protocol in Preventing Ventilator- Associated Pneumonia for Intensive Care Unit Patient

Acronym: VAP

Important dates

Study start
2007
Primary completion
2007
Study completion
2008
First posted
Jan 30, 2008
Registry last updated
Jan 30, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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