OrACELL™ vs. Connective Tissue in Miller Class 3 Defects

Twenty-four non-smoking, healthy patients, with 2mm or greater facial gingival recession at a minimum of one site that classified as a Miller Class I, II, or III recession defect were included. Patients were randomly assigned to either control (CTG) or OrACELL™ (test) groups, which were treated with identical surgical techniques. All root coverage clinical parameters were evaluated at baseline, 3-, and 6-months.

Inclusion criteria

• Patients must be between 18 and 80 years old, with recession present in one quadrant as either single or multiple buccal vertical recession sites
• The defect must be at least 2mm in length, (measured from the CEJ to the midfacial gingival margin) and classified as either Miller Class I, II or III
• Study is limited to vital and nonvital incisors, canines, and premolars
• If teeth adjacent to the site to be treated had recession as well, they were included in the grafting procedure but not included in measurement
• Plaque control defined as modified O'Leary Index of 85% was established before surgical intervention
• Only sites with probing depths of 3mm or less and no bleeding on probing were accepted for surgery

Exclusion criteria

• Subjects who smoke more than ten cigarettes per day or use nicotine replacement therapy
• History of previous history of surgery performed at surgical sites included in study
• Subjects who have uncontrolled or poorly controlled systemic conditions that could compromise or contraindicate periodontal surgery
• Non-English speakers
• Pregnant or lactating females
• Immunosuppressant medications