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NCT Number: NCT03997253

Optimizing Long-term Survival in Organ Transplantation: From Physiopathology to Optimized Patient Management

Increased indications for transplantation continue to worsen the shortage of organs and need the extension of graft sampling criteria and the search for new potential sources of organs. Despite undeniable success in the short term, due to major advances in surgery, medicine and research, transplant recipients continue to face the risk of chronic rejection and long-term complications.

The University Hospital Federation "FHU SUPORT" was created to optimize the chances of success of the organ transplant and improve the quality of life of the transplanted patient. FHU SUPORT 's ambition is based on a translational strategy that presents two priority areas:

Axis 1: Optimization, evaluation, conditioning of the donor, graft, recipient Axis 2: Personalized follow-up of the transplanted patient in the short and long term Identifying factors for long-term graft and patient survival through translational research from a common cohort and biological collection will predict transplant rejection, prolong graft function, or improve the patient's care.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Limoges hospital, Limoges, France

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female over 18 (no age limit)
  • affiliated to a social security organization
  • Recipient (s) of a kidney, liver or heart transplant
  • followed by at least one of the FHU SUPORT centers (Tours, Poitiers, Limoges, Rennes)
  • having given informed consent to participate in the cohort.

Exclusion criteria

  • Patient unable to understand the information given by the investigator
  • People under the protection of justice

Treatment and study plan

Blood and Urine samples

Other

various blood and urine samples will be collected from the recipient at D0, D7, D14, M1, M3, M6 and M12 and intraoperative bile collection

Primary outcomes

  1. Survival of the graft

    Time frame: 12 months

Study contacts

Contact information is provided by the study sponsor or research team.

Sophie ALAIN, MD

CONTACT

[email protected]

+33 5 55 056 728

Sponsors and collaborators

Lead sponsor

University Hospital, Limoges

Other

Collaborators

  • University Hospital Federation FHU SUPORT

Registry information

Acronym: BIOSUPORT

Important dates

Study start
2020
Primary completion
2027
Study completion
2027
First posted
Jun 25, 2019
Registry last updated
Jun 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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