Optimizing CNS DHA Delivery in Elderly Adults at Risk for Dementia

Inclusion criteria

• men and women 55 to 82 years old;
• presence of subjective cognitive decline or mild cognitive decline using the SCD questionnaire, DEX, EMQ, MoCA; and mCDR;
• No contraindication to a lumbar puncture (LP) unless opting to not have the LP (e.g., thrombocytopenia, coagulopathy, concomitant use of anticoagulant medications, etc.);
• fluency in English;
• ability to comprehend and comply with the research protocol; and
• provision of written informed consent.

Exclusion criteria

• diagnosis of dementia due to AD, Parkinson's disease, frontotemporal dementia, multi-infarct dementia, head trauma with loss of consciousness lasting more than 5 minutes and resulting in persisting functional decline within the three years prior to enrollment, epilepsy, leukoencephalopathy, other neurological conditions that would interfere the study objectives, mMIST <8 or MoCA-MI score <7;
• self-reported history of any psychotic disorder or bipolar disorder;
• diagnosis of atrial fibrillation, pancreatic, liver, kidney or hematological coagulation disorder;
• allergy to shellfish or seafood;
• current substance use causing physiological dependence or persisting change in functional capability;
• concomitant, regular use of medications that might affect primary outcome measures or adversely interact with the study product including anticoagulant medications;
• weekly fish consumption more than 1 x 3 oz servings and/or use of DHA-containing supplements within 3 months prior to screening.