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OpenTrials
Completed

NCT Number: NCT01949272

Optimization of PEEP for Alveolar Recruitment in ARDS

Actual setting of PEEP in ARDS is based on tables linked to FiO2, or respiratory system plateau pressure (e.g EXPRESS Study) or set regarding esophageal pressure mesurement and transpulmonary pressure calculation. Opera study should confirm if a setting approach based on esophageal pressure is helpfull for any ARDS patient in ICU without deleterious side-effect.

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Key information

Conditions

ARDS

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Melun Hospital ICU

Melun, 77000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ARDS Stades 2 and 3 with invasive ventilation (EXPRESS settings) within 3 to 12 hours

Exclusion criteria

  • less 18 years, pregnancy, intracardiac shunt, esophageal catheter cons-indicated

Treatment and study plan

esophageal pressure mesurement

Device

"EXPRESS study" ventilatory setting the optimization of PEEP with esophageal pressure mesurement

Primary outcomes

  1. PaO2/FiO2 ratio

    Time frame: 24 hours

Secondary outcomes

  1. Vd/Vt ratio

    Time frame: 24 hours

Sponsors and collaborators

Lead sponsor

Hopital of Melun

Other

Collaborators

  • Melun Hospital Intensive Care Unit

Registry information

Acronym: OPERA

Important dates

Study start
2013
Primary completion
2016
Study completion
2016
First posted
Sep 24, 2013
Registry last updated
Jun 27, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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