Department of Anesthesiology and Intensive Care Medicine (CCM/CVK), Charité - University Medicine Berlin
Berlin, 10117, Germany
NCT Number: NCT06511622
This is a retrospective observational study over the period 1/2019 - 02/2024 with the aim of identifying patients with a predisposition to secondary infections.
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Notify Me7 year and older
All sexes
Observational
Berlin, 10117, Germany
As a reference center, Charité Universitaetsmedizin Berlin has been treating patients with the most severe form of acute respiratory failure, known as acute respiratory distress syndrome (ARDS), for more than 30 years. Despite lung-protective forms of ventilation and the use of extracorporeal procedures for oxygenation and decarboxylation (ECMO), mortality is around forty percent. In addition to the primary cause of ARDS, further infectious complications often develop during the course of the disease, which delay recovery.
The aim of this study is to investigate infectious complications (ventilator-associated pneumonia, reactivation of Herpes viridae, pathogen resistance despite formally correct therapy, fungal infections) depending on the immune status.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Time frame: 01/2019- 12/2025
semi-quantitatively with Herpes simplex (negative / slightly positive / positive and strongly positive) in blood or bronchial lavage
Time frame: 01/2019- 12/2025
as absolute copy number per milliliter of blood or bronchioalveolar lavage
Time frame: 01/2019- 12/2025
absolute copy number per milliliter of blood or bronchioalveolar lavage
Time frame: 01/2019- 12/2025
Absolute number per nanoliter and percentage of lymphocytes
Time frame: 01/2019- 12/2025
Absolute number per nanoliter and percentage of lymphocytes.
Time frame: 01/2019- 12/2025
Aabsolute number per nanoliter and percentage of lymphocytes
Time frame: 01/2019- 12/2025
Absolute number per nanoliter and percentage of lymphocytes
Time frame: 01/2019- 12/2025
in molecules per cell
Time frame: 01/2019- 12/2025
Days until the first successful spontaneous breathing trial.
Time frame: 01/2019- 12/2025
Extracorporeal membrane oxygenation is measured in days
Time frame: 01/2019- 12/2025
Costs of treatment are measured by costs of particular microbiological diagnostics and therapy.
Time frame: 01/2019- 12/2025
Time frame: 01/2019- 12/2025
Time frame: 01/2019- 12/2025
Time frame: 01/2019- 12/2025
ITS mortality and hospital mortality are measured.
Time frame: 01/2019- 12/2025
Routine patient treatment data - score is measured numerically (0 - 24) Routine patient treatment data.
Time frame: 01/2019- 12/2025
Routine patient treatment data - score is measured numerically (0 - 163)
Time frame: 01/2019- 12/2025
Classified recording of previous illnesses (e.g. haematological diseases, tumour diseases, chronic heart failure, etc.) from the medical file.
Time frame: 01/2019- 12/2025
Results of microbiological diagnostics (growth- and molecular-based diagnostics) by specifying the name of the pathogen.
Time frame: 01/2019- 12/2025
Volumes administered, incl. transfusions and coagulation factors
Time frame: 01/2019- 12/2025
Recording of ventilation parameters such as airway, ventilation mode and start of ventilation weaning.
Time frame: 01/2019- 12/2025
Name of catecholamines, inotropes and vasopressors
Time frame: 01/2019- 12/2025
Number of days with dose of norepinephrine > 0.1 µg/kg/min for more than 30 min or equivalent dose of other catecholamines.
Time frame: 01/2019- 12/2025
Organ damage measured by routine laboratory
Time frame: 01/2019- 12/2025
Diagnoses as the cause of ARDS, but also newly acquired diagnoses such as critical illness myopathy / polyneuropathy, renal failure.
Time frame: 01/2019- 12/2025
Administration of immunosuppressants like corticosteroid, chemotherapy, monoclonal antibodies within the last 3 months.
Charite University, Berlin, Germany
Other
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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