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NCT Number: NCT07369817

Optimization and Testing of ALRITE, a Clinical Decision Support Tool for Management of Respiratory Illnesses in Young Children in Primary Care Health Facilities in Uganda

The goal of this study is to pilot test the feasibility of a mobile health clinical decision support tool called ALRITE for the diagnosis and management of acute lower respiratory illnesses in young children in Uganda. Asthma/wheezing illness, in particular, is underdiagnosed in this setting. The main questions the study aims to answer are:

* Are the intervention structure, processes, outcomes, and implementations strategies feasible to conduct in the desired settings? * Does ALRITE increase the diagnosis of wheezing illness among children seen at Ugandan health centers?

Researchers will compare outcomes before and after ALRITE deployment to healthcare workers at 4 Ugandan healthcare centers using an interrupted time series design. Study participants are healthcare workers.

There will be12 months of baseline data collection ("baseline period"), at the beginning of which healthcare workers will be enrolled at each site. Following the baseline period, health workers will receive ALRITE training and will be encouraged but not required to use ALRITE in clinical care for a 6-month intervention period. Health worker participants will fill out surveys and participate in focus group discussions to provide feedback.

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Key information

Conditions

Pneumonia Childhood Acute Lower Respiratory Illness Childhood Asthma Wheezing Lower Respiratory Illness

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthcare workers employed at each study site with a minimum of 6 months' experience of caring for children with respiratory symptoms in general outpatient care
  • Completed one of the following training programs: medical officer, clinical officer, nurse, midwife
  • proficient in reading and speaking English, one of the official languages of Uganda
  • at least 18 years of age

Exclusion criteria

  • inability to read/write English

Treatment and study plan

ALRITE

Other

ALRITE is a point-of-care mobile health clinical decision support tool designed for use by healthcare workers in Uganda. ALRITE guides the user into entering patient information and provides guideline-concordant recommendations. ALRITE also includes educational videos and weight-based dosing.

Primary outcomes

  1. Healthcare worker enrollment (study feasibility)

    Time frame: At enrollment

    Number of healthcare workers enrolled during the baseline phase and additional healthcare workers who were enrolled during the remaining study period (ex: new hires or transfers)

  2. Healthcare worker retention (study feasibility)

    Time frame: From enrollment through study completion, an average of 20 months

    Proportion of healthcare workers active in the study over total number enrolled

  3. Availability of ALRITE-enabled devices (study feasibility)

    Time frame: Monthly during the intervention period from ALRITE deployment through study completion, an average of 6 months

    Proportion of functional devices over number of devices provided to the facility per month

  4. ALRITE training completion (study feasibility)

    Time frame: During ALRITE deployment at the end of the baseline period, estimated 1-2 months

    Number of ALRITE training sessions completed per site

  5. Data completeness (study feasibility)

    Time frame: Monthly from baseline (day 1) through the study completion, estimated 20 months

    Percentage of eligible pediatric cases correctly abstracted from the health facility records into the electronic database.

Secondary outcomes

  1. Diagnosis rate of wheezing illness

    Time frame: Monthly from baseline through study completion, estimated 20 months

    Diagnosis rates of wheezing illness/asthma among all young children presenting to study sites, as recorded in the health record

  2. Diagnosis rate of pneumonia

    Time frame: Monthly from baseline through study completion, estimated 20 months

    Diagnosis rates of pneumonia among all young children presenting to study sites, as recorded in the health record

Study contacts

Contact information is provided by the study sponsor or research team.

Jane Edelson

CONTACT

[email protected]

206-779-9351

Sponsors and collaborators

Lead sponsor

University of Washington

Other

Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jan 27, 2026
Registry last updated
Jan 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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